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Mallika Sastry

National Institutes of Health - Vaccine Research Center

Bethesda, MD 20892-9806

United States

  • National Institutes of Health - Vaccine Research Center

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Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains

Number of pages: 65 Posted: 26 Oct 2020
Tongqing Zhou, Yaroslav Tsybovsky, Jason Gorman, Micah Rapp, Gabriele Cerutti, Gwo-Yu Chuang, Phinikoula S. Katsamba, Jared M. Sampson, Arne Schön, Jude Bimela, Jeffrey C. Boyington, Alexandra Nazzari, Adam S. Olia, Wei Shi, Mallika Sastry, Tyler Stephens, Jonathan Stuckey, I-Ting Teng, Pengfei Wang, Shuishu Wang, Baoshan Zhang, Richard A. Friesner, David D. Ho, John Mascola, Lawrence Shapiro and Peter D. Kwong
National Institutes of Health - Vaccine Research Center, Frederick National Laboratory for Cancer Research - Electron Microscopy Laboratory, National Institutes of Health - Vaccine Research Center, Columbia University - Department of Biochemistry and Molecular Biophysics, Columbia University - Department of Biochemistry and Molecular Biophysics, National Institutes of Health - Vaccine Research Center, Columbia University - Department of Biochemistry and Molecular Biophysics, Columbia University - Department of Biochemistry and Molecular Biophysics, Johns Hopkins University - Department of Biology, Columbia University - Department of Biochemistry and Molecular Biophysics, National Institutes of Health - Vaccine Research Center, National Institutes of Health - Vaccine Research Center, National Institutes of Health - Vaccine Research Center, National Institutes of Health - Vaccine Research Center, National Institutes of Health - Vaccine Research Center, Frederick National Laboratory for Cancer Research - Electron Microscopy Laboratory, National Institutes of Health - Vaccine Research Center, National Institutes of Health - Vaccine Research Center, Columbia University - Aaron Diamond AIDS Research Center, National Institutes of Health - Vaccine Research Center, National Institutes of Health - Vaccine Research Center, Columbia University - Department of Chemistry, Columbia University - Aaron Diamond AIDS Research Center, National Institutes of Health - Vaccine Research Center, National Institutes of Health - Vaccine Research Center and National Institutes of Health - Vaccine Research Center
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Abstract:

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ACE2 receptor, endosomal entry, pH-dependent switch, receptor-binding domain (RBD), structural rearrangement, type 1 fusion machine