University of California, San Diego (UCSD) - Department of Cellular and Molecular Medicine, affiliation not provided to SSRN, affiliation not provided to SSRN, University of California, San Diego (UCSD) - Department of Cellular and Molecular Medicine, affiliation not provided to SSRN, affiliation not provided to SSRN, Tongji University, German Center for Neurodegenerative Diseases (DZNE), Yale University, Whitehead Institute for Biomedical Research, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Massachusetts Institute of Technology and Harvard University - Broad Institute, Broad Institute of Harvard and MIT - Stanley Center for Psychiatric Research, Banner Health - Civin Laboratory for Neuropathology, Banner Health - Civin Laboratory for Neuropathology, University of Bonn - Institute of Innate Immunity, affiliation not provided to SSRN, affiliation not provided to SSRN, University of California, San Diego (UCSD), affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Imperial College London, affiliation not provided to SSRN and University of California, San Diego (UCSD) - Department of Cellular and Molecular Medicine