Heidelberg University - First Department of Medicine, University of Turin - Department of Clinical and Biological Sciences, - Clinical Hospital San Carlos, Heidelberg University - University Medical Center Mannheim, ForAnemia Foundation, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación, Sanitaria del Hospital Clínico San Carlos (IdISSC), Hospital Clínico de Valladolid - Cardiology Department, Hospital Universitario Guadalajara, Ente Ospedaliero Ospedali Galliera, Ospedale Pediatrico Microcitemico A. Cao - SSD Talassemia, IRCCS Istituto Giannina Gaslini, Fondazione IRCCS Policlinico San Matteo, University of Campania Luigi Vanvitelli - Department of Women, Children and General and Specialized Surgery, San Giovanni di Dio Ruggi d'Aragona, Ospedale Pediatrico Microcitemico A. Cao - SSD Talassemia, Unità Operativa Semplice Studio Emoglobinopatie Simt, University of Ferrara - Azienda Ospedaliero, Unità Operativa Semplice Studio Emoglobinopatie Simt, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione Garibaldi, Ospedale Giovanni Paolo II, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Mannheim, IRCCS Istituto Giannina Gaslini, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - Istituto Tumori “Giovanni Paolo II”, University of Milano-Bicocca, University of Milano-Bicocca, University of Padua - Azienda Ospedale Padova, Policlinico Umberto I, Policlinico Umberto I, Policlinico Umberto I, University of Campania Luigi Vanvitelli - Department of Women, Children and General and Specialized Surgery, Azienda Ospedaliero – Universitaria Policlinico – Vittorio Emanuele, University of Campania “Luigi Vanvitelli” - Department of Women’s and Children’s Health, Azienda Ospedaliero – Universitaria Policlinico – Vittorio Emanuele, University of Turin, Fondazione IRCCS Policlinico San Matteo, Hospital Universitario Getafe, Hospital Universitario La Paz, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación, Sanitaria del Hospital Clínico San Carlos (IdISSC), Hospital Universitario Central de Asturias, Lambung Mangkurat University - Hematology-Oncology Division, Hospital Puerta de Hierro de Majadahonda - Cardiology Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Campania “Luigi Vanvitelli” - Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Policlinico GB Rossi, University of Turin - Department of Clinical and Biological Sciences, Ente Ospedaliero Ospedali Galliera and Heidelberg University - First Department of Medicine

Heidelberg University - University Medical Center Mannheim, - Clinical Hospital San Carlos, Heidelberg University - First Department of Medicine, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación, Sanitaria del Hospital Clínico San Carlos (IdISSC), Hospital Clínico Universitario Virgen de la Victoria, Departamento de Cardiología, Hospital Clínico Universitario de Valladolid, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación, Sanitaria del Hospital Clínico San Carlos (IdISSC), Hospital Nuestra Señora de América, Hospital Universitario Guadalajara, Centro Cardiologico Monzino, IRCCS, Universidade de Santiago de Compostela - Cardiology Department, Azienda Ospedaliero-Universitaria Consorziale Policlinico Di Bari, Hospital Universitario Getafe, Hospital General del norte de Guayaquil IESS Los Ceibos, San Luigi Gonzaga University Hospital, Orbassano and Rivoli Infermi Hospital, Hospital Virgen del Mar, University of Turin - Department of Cardiology, Hospital IMED, Hospital Clínico de Valencia, INCLIVA, Hospital Clínico Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Fondazione Policlinico Universitario A. Gemelli IRCCS - Department of Woman and Child Health and Public Health, University Hospital Joan XXIII, Heidelberg University - Department of Medical Statistics and Biomathematics, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación, Sanitaria del Hospital Clínico San Carlos (IdISSC), Instituto Cardiovascular, Hospital Clínico San Carlos and Heidelberg University - First Department of Medicine