Heidelberg University - University Medical Center Mannheim, - Clinical Hospital San Carlos, Heidelberg University - First Department of Medicine, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación, Sanitaria del Hospital Clínico San Carlos (IdISSC), Hospital Clínico Universitario Virgen de la Victoria, Departamento de Cardiología, Hospital Clínico Universitario de Valladolid, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación, Sanitaria del Hospital Clínico San Carlos (IdISSC), Hospital Nuestra Señora de América, Hospital Universitario Guadalajara, Centro Cardiologico Monzino, IRCCS, Universidade de Santiago de Compostela - Cardiology Department, Azienda Ospedaliero-Universitaria Consorziale Policlinico Di Bari, Hospital Universitario Getafe, Hospital General del norte de Guayaquil IESS Los Ceibos, San Luigi Gonzaga University Hospital, Orbassano and Rivoli Infermi Hospital, Hospital Virgen del Mar, University of Turin - Department of Cardiology, Hospital IMED, Hospital Clínico de Valencia, INCLIVA, Hospital Clínico Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Fondazione Policlinico Universitario A. Gemelli IRCCS - Department of Woman and Child Health and Public Health, University Hospital Joan XXIII, Heidelberg University - Department of Medical Statistics and Biomathematics, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación, Sanitaria del Hospital Clínico San Carlos (IdISSC), Instituto Cardiovascular, Hospital Clínico San Carlos and Heidelberg University - First Department of Medicine