University of Bristol - Bristol Medical School, Queen Mary University of London - Wolfson Institute of Population Health, affiliation not provided to SSRN, Belfast Health and Social Care Trust, affiliation not provided to SSRN, University Hospitals of Derby and Burton NHS Foundation Trust, Nottingham Breast Institute, affiliation not provided to SSRN, Queen's University Belfast, University of Birmingham - University Hospital Birmingham NHS Foundation Trust and Institute of Cancer and Genomic Science, affiliation not provided to SSRN, University of Leeds - St. James's University Hospital and affiliation not provided to SSRN