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affiliation not provided to SSRN, University of Valladolid - Universidad de Valladolid, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, BioCritic. Group for Biomedical Research in Critical Care Medicine, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Valladolid - Universidad de Valladolid, BioCritic. Group for Biomedical Research in Critical Care Medicine, affiliation not provided to SSRN, affiliation not provided to SSRN, BioCritic. Group for Biomedical Research in Critical Care Medicine, BioCritic. Group for Biomedical Research in Critical Care Medicine, affiliation not provided to SSRN and Hospital Clínico de Valladolid