University of Valladolid - Clinical Hospital, University of Valencia - Faculty of Medicine, University of Barcelona - Faculty of Medicine, BioCritic. Group for Biomedical Research in Critical Care Medicine, Hospital Clinico San Carlos, Hospital Clínico de Valladolid, Hospital Universitario de Fuenlabrada, University Hospital Marques de Valdecilla - Department of Anesthesiology, University Hospital Ribera Povisa - Department of Anesthesiology, University Hospital of Gran Canaria Dr. Negrin, University Hospital of Gran Canaria Dr. Negrin, University Hospital of Manises - Department of Anesthesiology, University of Barcelona - Faculty of Medicine, Hospital Universitario de Salamanca, University of Valladolid - Clinical Hospital, Parc Taulí Hospital Universitari, University Hospital Álvaro Cunqueiro - Department of Anesthesiology, University Hospital of Donostia - Department of Anesthesiology, University Hospital Álvaro Cunqueiro - Department of Anesthesiology, Castellon University - Castellon University General Hospital, Hospital Universitario Lucus Augusti (HULA), Universidade de Santiago de Compostela - Faculty of Medicine, University of Valencia - Department of Anaesthesia, Hospital San Pau - Department of Anesthesiology, University of A Coruña - Department of Anesthesiology, Hospital Universitario Cruces, University Hospital of Cabueñes - Department of Anesthesiology, Miguel Servet University Hospital, Hospital Universitario de León, Instituto de Investigación Sanitaria Hospital "12 de Octubre" - Hospital Universitario 12 de Octubre, University of the Basque Country - Hospital de Cruces, BioCritic. Group for Biomedical Research in Critical Care Medicine, University of the Basque Country - Hospital de Cruces, University Hospital of Bellvitge, University of Valladolid - Clinical Hospital, BioCritic. Group for Biomedical Research in Critical Care Medicine, BioCritic. Group for Biomedical Research in Critical Care Medicine, Hospital Universitario Basurto, University Hospital Álvaro Cunqueiro - Department of Anesthesiology, Hospital Universitario de Salamanca, Ferrol University Hospital Complex - Department of Anesthesiology, University Hospital Puerta del Hierro - Department of Anesthesiology, University of Burgos - Hospital Universitario de Burgos, Hospital Universitario Central de Asturias, Hospital Universitario San Cecilio de Granada, Hospital Clínico Universitario Valladolid, University Hospital of Tajo - Department of Anesthesiology, Monforte de Lemos Hospital - Department of Anesthesiology, University Hospital Complex of Ourense - Department of Anesthesiology, Quirón Salud Valle del Henares Hospital - Department of Anesthesiology, University Hospital of Pontevedra - Department of Anaesthesiology, University of Valencia - Department of Anesthesiology and Intensive Care, University of Valladolid - Clinical Hospital, BioCritic. Group for Biomedical Research in Critical Care Medicine, BioCritic. Group for Biomedical Research in Critical Care Medicine, University of Valencia - Department of Anesthesiology and Intensive Care and Independent

affiliation not provided to SSRN, University of Valladolid - Universidad de Valladolid, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, BioCritic. Group for Biomedical Research in Critical Care Medicine, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Valladolid - Universidad de Valladolid, BioCritic. Group for Biomedical Research in Critical Care Medicine, affiliation not provided to SSRN, affiliation not provided to SSRN, BioCritic. Group for Biomedical Research in Critical Care Medicine, BioCritic. Group for Biomedical Research in Critical Care Medicine, affiliation not provided to SSRN and Hospital Clínico de Valladolid