University of Amsterdam - Amsterdam UMC, University of Amsterdam - Amsterdam UMC, University of Amsterdam - Amsterdam UMC, University of Amsterdam - Amsterdam UMC, University of Insubria, Linkoping University - Linköping University Hospital, University of Pisa - Department of Translational Research on New Technologies in Medicine and Surgery, University of Gothenburg - Sahlgrenska University Hospital, University of Amsterdam - Amsterdam UMC, Pederzoli Hospital-Peschiera del Garda, Istituto Clinico Humanitas, Università di Bologna, Beaujon Hospital, University of Oslo - Institute of Clinical Medicine, University Hospital of Verona, Università Vita-Salute San Raffaele - IRCCS Ospedale San Raffaele, Grande Ospedale Metropolitano Niguarda, University of Hamburg - University Medical Center Hamburg-Eppendorf, University of Amsterdam - Cancer Center Amsterdam, Erasmus University Rotterdam (EUR) - Department of Surgery, University of Groningen - Department of Surgery, Schleswig-Holstein University, University of Oslo - Oslo University Hospital, University of Helsinki, Emory University - Emory University Hospital, Medisch Spectrum Twente, Catharina Hospital - Department of Surgery, Fondazione Poliambulanza Istituto Ospedaliero, University of Birmingham, King’s College London - Institute of Liver Studies, University Medical Center Utrecht, University Hospital of Verona, Università Vita-Salute San Raffaele - IRCCS Ospedale San Raffaele, University of Southampton, Regione Emilia-Romagna - Division of Pancreatic Surgery, University Hospital of Orléans - Department of Digestive and Endocrine Surgery, University of Verona - Department of General and Pancreatic Surgery, Linkoping University - Linköping University Hospital, Government of the United Kingdom - Royal Free London NHS Foundation Trust, University of Ljubljana - University Medical Centre Ljubljana, UKSH Campus Lübeck - Department of Surgery, Istituto Clinico Humanitas, Fondazione Poliambulanza Istituto Ospedaliero, University of Amsterdam - Department of Clinical Epidemiology, Biostatistics and Bioinformation, University of Amsterdam - Amsterdam University Medical Centers, University of Jordan and Independent

Biodonostia Health Research Institute - Department of Liver and Gastrointestinal Diseases, The Christie NHS Foundation Trust - Department of Medical Oncology, Biodonostia Health Research Institute - Department of Liver and Gastrointestinal Diseases, Erasmus MC University Medical Center - Department of Surgery, University of Regensburg - Institute of Pathology, University of Amsterdam - Cancer Center Amsterdam, Department of Medical Oncology, Hospital Universitario 12 de Octubre - Department of Medical Oncology, Hannover Medical School - Department of Gastroenterology, Hepatology and Endocrinology, Humanitas University - Division of Internal Medicine and Hepatology, University of Padua - DMM Department of Molecular Medicine, Universidad de Navarra - Clinica Universidad de Navarra and Program in Solid Tumors (CIMA), Sorbonne Université - Department of Hepatobiliary and Liver Transplantation Surgery, Sapienza University of Rome - Translational and Precision Medicine, University of Glasgow - Institute of Cancer Sciences, University of Sassari - Department of Medical, Surgical and Experimental Sciences, University of Glasgow - Institute of Cancer Sciences, Carlos III National Institute of Health - Center for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Klinik Favoriten - Department for Surgery, Università Politecnica delle Marche - Department of Gastroenterology, Medical University of Warsaw - Department of General, Transplant and Liver Surgery, Oslo University Hospital Rikshospitalet - Norwegian PSC Research Center, Department of Transplantation Medicine, Lithuanian University of Health Sciences - Department of Gastroenterology and Institute for Digestive Research, University of Medicine and Pharmacy - Institute for Gastroenterology and Hepatology, 3rd Medical Department, Saarland University - Department of Medicine II, Teaching Hospital No. 1 - of Gastroenterology and Hepatology with General Medicine Unit, Grigore T. Popa University of Medicine and Pharmacy - Department of Morpho-Functional Sciences I, Biodonostia Health Research Institute - Department of Liver and Gastrointestinal Diseases, Erasmus MC University Medical Center - Department of Surgery, University of Regensburg - Institute of Pathology, University of Amsterdam - Department of Surgery, Hospital Universitario 12 de Octubre - Department of Medical Oncology, Hannover Medical School - Department of Gastroenterology, Hepatology and Endocrinology, University of Regensburg - Institute of Pathology, Biodonostia Health Research Institute - Department of Liver and Gastrointestinal Diseases, Sapienza University of Rome - Department of Movement, Human and Health Sciences, University of Copenhagen - Biotech Research and Innovation Centre, University of Salamanca - Experimental Hepatology and Drug Targeting (HEVEPHARM) Group, Sapienza University of Rome - Translational and Precision Medicine, Biodonostia Health Research Institute - Department of Liver and Gastrointestinal Diseases, Instituto de Salud Carlos III” (ISCIII) - National Institute for the Study of Liver and Gastrointestinal Diseases, CIBERehd, The Christie NHS Foundation Trust - Department of Medical Oncology, Erasmus University Rotterdam (EUR) - Department of Surgery and University of the Basque Country - Department of Liver and Gastrointestinal Diseases

Netherlands Cancer Institute, Netherlands Cancer Institute, Netherlands Cancer Institute, Erasmus University Rotterdam (EUR), Erasmus University Rotterdam (EUR) - Department of Surgery, Erasmus University Medical Center Rotterdam - Department of General Surgery, Erasmus University Medical Center Rotterdam - Erasmus MC Cancer Institute, Erasmus University Rotterdam (EUR), Netherlands Cancer Institute - Department of Pathology, Netherlands Cancer Institute, Netherlands Cancer Institute, Netherlands Cancer Institute, Netherlands Cancer Institute, Netherlands Cancer Institute, Netherlands Cancer Institute, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, Netherlands Cancer Institute, Netherlands Cancer Institute and Netherlands Cancer Institute

affiliation not provided to SSRN, Utrecht University - University Medical Center (Utrecht), affiliation not provided to SSRN, affiliation not provided to SSRN, University of Amsterdam - Amsterdam UMC, University of Amsterdam - Amsterdam University Medical Centers, Utrecht University - University Medical Center (Utrecht), affiliation not provided to SSRN, Onze Lieve Vrouwen Gasthuis, Catharina Hospital, Erasmus University Medical Center Rotterdam - Medical Oncology, Utrecht University - University Medical Center (Utrecht), Medisch Spectrum Twente, affiliation not provided to SSRN, University of Groningen - Department of Gastroenterology and Hepatology, affiliation not provided to SSRN, Radboud University, affiliation not provided to SSRN, University of Amsterdam - Amsterdam UMC, University Medical Center Utrecht, St. Antonius Hospital, Erasmus University Rotterdam (EUR) - Department of Surgery and Erasmus University Rotterdam (EUR) - Department of Surgery

affiliation not provided to SSRN, affiliation not provided to SSRN, University of Amsterdam - Amsterdam UMC, Erasmus University Medical Center Rotterdam - Medical Oncology, Maastricht University - GROW School for Oncology and Reproduction, Erasmus University Rotterdam (EUR) - Department of Surgery, affiliation not provided to SSRN, Erasmus University Rotterdam (EUR) - Department of Surgery, affiliation not provided to SSRN and Erasmus University Rotterdam (EUR) - Department of Surgery

Erasmus University Rotterdam (EUR) - Department of Surgery, Erasmus University Medical Center Rotterdam - Department of Pathology Unit of Tumor Immuno-Pathology, Erasmus University Rotterdam (EUR) - Department of Surgery, Erasmus University Rotterdam (EUR) - Department of Surgery, Erasmus University Rotterdam (EUR) - Department of Surgery, Erasmus University Medical Center Rotterdam - Medical Oncology, Leiden University - Department of Medical Oncology,, Erasmus University Rotterdam (EUR) - Department of Surgery and Erasmus University Medical Center Rotterdam - Department of Pathology Unit of Tumor Immuno-Pathology

Maastricht University, Maastricht University, University of Amsterdam - Amsterdam UMC, affiliation not provided to SSRN, Utrecht University - University Medical Center (Utrecht), affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Maastricht University, affiliation not provided to SSRN, Onze Lieve Vrouwen Gasthuis, Jeroen Bosch Hospital, Amphia Hospital, affiliation not provided to SSRN, affiliation not provided to SSRN, Leiden University, Medisch Spectrum Twente, affiliation not provided to SSRN, Maastricht University - GROW School for Oncology and Reproduction, Catharina Hospital, University of Duisburg-Essen - Bridge Institute of Experimental Tumor Therapy, University of Groningen, University of Groningen, University of Groningen - Department of Gastroenterology and Hepatology, Erasmus University Rotterdam (EUR) - Department of Surgery, University of Amsterdam - Amsterdam UMC, University of Amsterdam - Cancer Center Amsterdam, University of Amsterdam - Amsterdam University Medical Centers, University Medical Center Utrecht, Utrecht University - University Medical Center (Utrecht), affiliation not provided to SSRN, Maastricht University, affiliation not provided to SSRN and Maastricht University

affiliation not provided to SSRN, Utrecht University - University Medical Center (Utrecht), affiliation not provided to SSRN, Utrecht University - University Medical Center (Utrecht), Erasmus University Rotterdam (EUR) - Department of Surgery, Erasmus University Rotterdam (EUR) - Department of Surgery, Isala Zwolle, affiliation not provided to SSRN, Maastricht University - GROW School for Oncology and Reproduction, University of Amsterdam - Amsterdam UMC, University Medical Center Utrecht, affiliation not provided to SSRN and St. Antonius Hospital