Biodonostia Health Research Institute - Department of Liver and Gastrointestinal Diseases, The Christie NHS Foundation Trust - Department of Medical Oncology, Biodonostia Health Research Institute - Department of Liver and Gastrointestinal Diseases, Erasmus MC University Medical Center - Department of Surgery, University of Regensburg - Institute of Pathology, University of Amsterdam - Cancer Center Amsterdam, Department of Medical Oncology, Hospital Universitario 12 de Octubre - Department of Medical Oncology, Hannover Medical School - Department of Gastroenterology, Hepatology and Endocrinology, Humanitas University - Division of Internal Medicine and Hepatology, University of Padua - DMM Department of Molecular Medicine, Universidad de Navarra - Clinica Universidad de Navarra and Program in Solid Tumors (CIMA), Sorbonne Université - Department of Hepatobiliary and Liver Transplantation Surgery, Sapienza University of Rome - Translational and Precision Medicine, University of Glasgow - Institute of Cancer Sciences, University of Sassari - Department of Medical, Surgical and Experimental Sciences, University of Glasgow - Institute of Cancer Sciences, Carlos III National Institute of Health - Center for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Klinik Favoriten - Department for Surgery, Università Politecnica delle Marche - Department of Gastroenterology, Medical University of Warsaw - Department of General, Transplant and Liver Surgery, Oslo University Hospital Rikshospitalet - Norwegian PSC Research Center, Department of Transplantation Medicine, Lithuanian University of Health Sciences - Department of Gastroenterology and Institute for Digestive Research, University of Medicine and Pharmacy - Institute for Gastroenterology and Hepatology, 3rd Medical Department, Saarland University - Department of Medicine II, Teaching Hospital No. 1 - of Gastroenterology and Hepatology with General Medicine Unit, Grigore T. Popa University of Medicine and Pharmacy - Department of Morpho-Functional Sciences I, Biodonostia Health Research Institute - Department of Liver and Gastrointestinal Diseases, Erasmus MC University Medical Center - Department of Surgery, University of Regensburg - Institute of Pathology, University of Amsterdam - Department of Surgery, Hospital Universitario 12 de Octubre - Department of Medical Oncology, Hannover Medical School - Department of Gastroenterology, Hepatology and Endocrinology, University of Regensburg - Institute of Pathology, Biodonostia Health Research Institute - Department of Liver and Gastrointestinal Diseases, Sapienza University of Rome - Department of Movement, Human and Health Sciences, University of Copenhagen - Biotech Research and Innovation Centre, University of Salamanca - Experimental Hepatology and Drug Targeting (HEVEPHARM) Group, Sapienza University of Rome - Translational and Precision Medicine, Biodonostia Health Research Institute - Department of Liver and Gastrointestinal Diseases, Instituto de Salud Carlos III” (ISCIII) - National Institute for the Study of Liver and Gastrointestinal Diseases, CIBERehd, The Christie NHS Foundation Trust - Department of Medical Oncology, Erasmus University Rotterdam (EUR) - Department of Surgery and University of the Basque Country - Department of Liver and Gastrointestinal Diseases

affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of the Basque Country - Department of Liver and Gastrointestinal Diseases and affiliation not provided to SSRN

University of Copenhagen - Biotech Research and Innovation Centre, University of the Basque Country - Department of Liver and Gastrointestinal Diseases, Owl Metabolomics, Owl Metabolomics, University of Copenhagen - Biotech Research and Innovation Centre, University of the Basque Country - Department of Liver and Gastrointestinal Diseases, University of the Basque Country - Department of Liver and Gastrointestinal Diseases, Hospital Juan Ramón Jiménez, University of Seville - UCM Digestive Diseases, Pontificia Universidad Católica de Chile - Department of Gastroenterology, University of Copenhagen - Center for Clinical Metabolic Research, University of Copenhagen - Center for Clinical Metabolic Research, Aarhus University - Department of Hepatology and Gastroenterology, Aarhus University - Department of Hepatology and Gastroenterology, Grenoble Université, Students, University of São Paulo (USP) - Department of Gastroenterology, University of São Paulo (USP) - Department of Gastroenterology, Carlos III National Institute of Health - Center for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Institute of Health - Center for the Study of Liver and Gastrointestinal Diseases (CIBERehd), University of the Basque Country - Department of Liver and Gastrointestinal Diseases and University of Copenhagen - Biotech Research and Innovation Centre