Stellenbosch University - Department of Paediatrics and Child Health, University of California, San Diego (UCSD), University of the Witwatersrand, Stellenbosch University - Children’s Infectious Diseases Clinical Research Unit (KID-CRU), Harvard University - Department of Biostatistics, Harvard University - Department of Biostatistics, University of the Witwatersrand, University of Cape Town - Division of Clinical Pharmacology, Yeshiva University - Jacobi Medical Center, Frontier Science Foundation, National Institutes of Health (NIH) - Division of AIDS, National Institutes of Health (NIH) - Division of Extramural Research, University of the Witwatersrand, Stellenbosch University, Stellenbosch University, Boston University - Chobanian & Avedisian School of Medicine, Chiang Mai University - PHPT/IRD and Independent