University of Birmingham - Institute of Immunology and Immunotherapy, University of Limerick - Health Research Institute and the Bernal Institute, University of Birmingham - Institute of Cancer and Genomic Sciences, University of Warwick - Division of Biomedical Sciences, University of Warwick - Bioinformatics Research Technology Platform, University of Warwick - Division of Biomedical Sciences, University of Limerick - Health Research Institute and the Bernal Institute, Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham Women’s and Children’s NHS Foundation Trust, University Hospitals Birmingham NHS Foundation Trust - Heartlands Hospital, Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham Women’s and Children’s NHS Foundation Trust - Paediatric Intensive Care Unit, Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham Women’s and Children’s NHS Foundation Trust, University Hospitals Birmingham NHS Foundation Trust - Heartlands Hospital, University of Birmingham - Clinical Immunology Service, University of Birmingham - Clinical Immunology Service, Cardiff University - Systems Immunity Research Institute, Cardiff University - Systems Immunity Research Institute, University of Birmingham - NIHR Birmingham Biomedical Research Centre and Institute of Cancer and Genomic Sciences and University of Birmingham - Institute of Immunology and Immunotherapy