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Stefan Somlo

Yale University - Section of Nephrology

New Haven, CT

United States

  • Yale University - Section of Nephrology

SCHOLARLY PAPERS

2

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100

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Scholarly Papers (2)

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1.

A Synthetic Agent Ameliorates Polycystic Kidney Disease by Promoting Apoptosis of Cystic Cells Through Increased Oxidative Stress

Number of pages: 57 Posted: 25 Oct 2021
Bogdan I. Fedeles, Sorin V. Fedeles, Yasunobu Ishikawa, Sakunchai Khumsubdee, Matteus Krappitz, Nina Gubina, Denise C. Andrade, Parisa Westergerling, Tobias Staudner, Jake Campolo, Sally S. Liu, Ke Dong, Yiqiang Cai, Anna Rachel Gallagher, Somsak Ruchirawat, Robert G. Croy, John M. Essigmann and Stefan Somlo
Massachusetts Institute of Technology - Departments of Biological Engineering, Chemistry and Center for Environmental Health Sciences, Yale University - Section of Nephrology, Yale University - Section of Nephrology, Massachusetts Institute of Technology (MIT), Yale University - Section of Nephrology, Massachusetts Institute of Technology (MIT), Massachusetts Institute of Technology (MIT), Yale University - Section of Nephrology, Yale University - Section of Nephrology, Massachusetts Institute of Technology (MIT), Massachusetts Institute of Technology (MIT), Yale University - Section of Nephrology, Yale University - Section of Nephrology, Yale University - Section of Nephrology, Chulabhorn Research Institute, Massachusetts Institute of Technology (MIT) - Department of Biological Engineering, Massachusetts Institute of Technology - Departments of Biological Engineering, Chemistry and Center for Environmental Health Sciences and Yale University - Section of Nephrology
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PKD, mouse model, cystic disease, drug discovery, target validation, lead optimization, oxidative stress, apoptosis

2.

The C-Terminal Tail of Polycystin-1 Suppresses Cystic Disease in a Mitochondrial Enzyme-Dependent Fashion

Number of pages: 75 Posted: 29 Dec 2021
Laura Onuchic, Valeria Padovano, Giorgia Schena, Vanathy Rajendran, Ke Dong, Nikolay P. Gresko, Xiaojian Shi, Hongying Shen, Stefan Somlo and Michael J. Caplan
affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Yale University - Section of Nephrology, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Yale University - Section of Nephrology and affiliation not provided to SSRN
Downloads 38 (1,249,711)

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Autosomal dominant polycystic kidney disease (ADPKD), Nicotinamide nucleotide transhydrogenase (NNT), metabolism, Polycystin-1 (PC1), Mitochondria, C-terminal tail (CTT)