affiliation not provided to SSRN, Institute for Neuropathology - Sano Centre for Computational Medicine, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, National Institutes of Health - Laboratory of Neurogenetics, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Government of the United States of America - National Institute of Neurological Disorders and Stroke (NINDS), affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University College London - UCL Queen Square Institute of Neurology, affiliation not provided to SSRN, University College London - Department of Molecular Neuroscience, University College London - Department of Molecular Neuroscience, Harvard University - Department of Neurology and University of Zurich - Institute of Neuropathology