Kyushu University - Department of Cardiovascular Medicine, Kyushu University - Department of Cardiovascular Medicine, Kyushu University - Center for Clinical and Translational Research, International University of Health and Welfare Hospital (IUHW) - Pulmonary Hypertension Center, Kyushu University - Center for Clinical and Translational Research, Kyushu University - Center for Clinical and Translational Research, Kobe University - Division of Cardiovascular Medicine, Kyorin University - Department of Cardiovascular Medicine, Nagoya University - Department of Cardiology, Hokkaido University - Division of Respiratory and Cardiovascular Innovative Research, Tokyo Medical University - Department of Cardiology, National Cerebral and Cardiovascular Centre - Division of Pulmonary Circulation, Toho University - Ohashi Medical Center, Toho University - Division of Cardiovascular Medicine, National Hospital Organization, Osaka National Hospital, Department of Cardiology, Keio University - Department of Cardiology, National Cerebral and Cardiovascular Centre - Division of Pulmonary Circulation, Tokyo Medical University - Department of Cardiovascular Surgery, Kurume University - Division of Cardiovascular Medicine, Chibaken Saiseikai Narashino Hospital - Pulmonary Hypertension Center, National Hospital Organization Okayama Medical Centre - Department of Cardiology, Keio University - Department of Cardiology, Chiba University - Department of Respirology and Kyushu University - Department of Cardiovascular Medicine