University of Toronto - Interdepartmental Division of Critical Care Medicine, University of Toronto - Institute of Health Policy, Management and Evaluation, University of Toronto - Institute of Health Policy, Management and Evaluation, University of Toronto - Institute of Health Policy, Management and Evaluation, University of Amsterdam - Intelligent Systems Laboratory Amsterdam (ISLA), University of Toronto - Leslie Dan Faculty of Pharmacy, University of Toronto - Interdepartmental Division of Critical Care Medicine, University of Toronto - Interdepartmental Division of Critical Care Medicine, Massachusetts Institute of Technology (MIT) - Laboratory for Computational Physiology, University of Amsterdam - Intelligent Systems Laboratory Amsterdam (ISLA), University of Amsterdam - Intelligent Systems Laboratory Amsterdam (ISLA), University of Toronto - Interdepartmental Division of Critical Care Medicine, University of Toronto - Institute of Health Policy, Management and Evaluation, University of Toronto - Department of Medicine, University of Toronto - Institute of Health Policy, Management and Evaluation and University of Toronto - Institute of Health Policy, Management and Evaluation