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Carlos Pablo Modenutti

University of Buenos Aires (UBA) - Facultad de Ciencias Exactas y Naturales

Pabellón 2, Piso 1

Buenos Aires, Buenos Aires 1428

Argentina

SCHOLARLY PAPERS

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Scholarly Papers (1)

1.

A Quinolin-8-Ol Sub-Millimolar Inhibitor of UGGT, the ER Glycoprotein Folding Quality Control Checkpoint

Number of pages: 43 Posted: 06 Dec 2022
University of Massachusetts Amherst - Department of Biochemistry and Molecular Biology, University of Oxford - Oxford Glycobiology Institute, University of Oxford - Oxford Glycobiology Institute, Institute of Sciences of Food Production, University of Trento - Department of Cellular, Computational and Integrative Biology, University of Edinburgh - Wellcome Centre for Cell Biology, University of Oxford - Oxford Glycobiology Institute, University of Oxford - Oxford Glycobiology Institute, University of Oxford - Oxford Glycobiology Institute, Biomedical Manufacturing, Commonwealth Scientific and Industrial Research Organisation, University of Buenos Aires (UBA) - Facultad de Ciencias Exactas y Naturales, University of Milano - Department of Biosciences, University of Oxford - Oxford Glycobiology Institute, University of British Columbia (UBC) - Department of Chemistry, University of Oxford - Oxford Glycobiology Institute, University of Oxford - Oxford Glycobiology Institute, University of Buenos Aires (UBA) - Facultad de Ciencias Exactas y Naturales, University of British Columbia (UBC) - Department of Chemistry, University of Buenos Aires (UBA) - Facultad de Ciencias Exactas y Naturales, University of Trento - Department of Cellular, Computational and Integrative Biology, Institute of Sciences of Food Production, University of Massachusetts Amherst - Department of Biochemistry and Molecular Biology, University of Oxford - Department of Biochemistry and University of Milan - Department of Biosciences
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Abstract:

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UGGT inhibitor, CtUGGTGT24, 5-[(morpholin-4-yl)methyl]quinolin-8-ol, X-ray crystallography, fragment-based lead discovery, saturation transfer difference NMR spectroscopy