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Pierre Fraikin

University of Liège

Leige

Belgium

  • University of Liège

SCHOLARLY PAPERS

2

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84

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Scholarly Papers (2)

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1.

New Insights In The Development of Positive Allosteric Modulators of A-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) Receptors Belonging To 3,4-Dihydro-2H-1,2,4-Benzothiadiazine 1,1-Dioxides: Introduction of (Mono/Difluoro)Methyl Groups At The 2-Position of the Thiadiazine Ring

Number of pages: 36 Posted: 23 Jan 2023
Eric Goffin, Pierre Fraikin, Dayana Abboud, Pascal de Tullio, Caroline Beaufour, Iuliana Botez, Julien Hanson, Laurence Danober, Pierre Francotte and Bernard Pirotte
University of Liège, University of Liège, University of Liège, University of Liège, Institut de Recherches Servier, Institut de Recherches Servier, University of Liège - Laboratory of Molecular Pharmacology, Institut de Recherches Servier, University of Liège and University of Liège
Downloads 49 (1,074,648)

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Ionotropic glutamate receptors, 1, 2, 4-benzothiadiazine 1, 1-dioxides, positive allosteric modulator, cognitive enhancer, N-mono/difluoromethyl-substituted compounds

2.

Exploring Thienothiadiazine Dioxides as Isosteric Analogues of Benzo- and Pyridothiadiazine Dioxides in the Search of New AMPA and Kainate Receptor Positive Allosteric Modulators

Number of pages: 42 Posted: 01 Nov 2023
Pierre Francotte, Yasmin Bay, Eric Goffin, Thomas Colson, Cindy Lesenfants, Jerzy Dorosz, Saara Laulumaa, Pierre Fraikin, Pascal de Tullio, Caroline Beaufour, Iuliana Botez, Darryl S. Pickering, Karla Frydenvang, Laurence Danober, Anders Skov Kristensen, Jette Sandholm Kastrup and Bernard Pirotte
University of Liège, University of Copenhagen, University of Liège, University of Liège, University of Liège, University of Copenhagen, University of Helsinki - Institute of Biotechnology, University of Liège, University of Liège, Institut de Recherches Servier, Institut de Recherches Servier, University of Copenhagen, University of Copenhagen, Institut de Recherches Servier, University of Copenhagen, University of Copenhagen and University of Liège
Downloads 35 (1,263,436)

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Ionotropic glutamate receptors, positive allosteric modulators, thieno[3, 2-e]-1, 2, 4-thiadiazine 1, 1-dioxides, 1, 2, 4-benzothiadiazine 1, 1-dioxides, X-ray crystallography, calcium-sensitive fluorescence-based assay