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Serge Przedborski

Columbia University - Center for Motor Neuron Biology and Disease

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Depletion of Mettl3 in Cholinergic Neurons Causes Adult-Onset Neuromuscular Degeneration

Number of pages: 48 Posted: 08 May 2023
Georgia Dermentzaki, Mattia Furlan, Iris Tanaka, Tommaso Leonardi, Patricia M.S. Passos, Alliny Bastos, Yuna Ayala, Jacob H. Hanna, Serge Przedborski, Dario Bonanomi, Mattia Pelizzola, Francesco Lotti and Sneak Peek Administrator
Columbia University - Center for Motor Neuron Biology and Disease, Fondazione Istituto Italiano di Tecnologia (IIT) - Center for Genomic Science, Fondazione Istituto Italiano di Tecnologia (IIT) - Center for Genomic Science, Fondazione Istituto Italiano di Tecnologia (IIT) - Center for Genomic Science, Saint Louis University - Department of Biochemistry and Molecular Biology, Saint Louis University - Department of Biochemistry and Molecular Biology, Saint Louis University - Department of Biochemistry and Molecular Biology, Weizmann Institute of Science - Department of Molecular Genetics, Columbia University - Center for Motor Neuron Biology and Disease, Università Vita-Salute San Raffaele - Division of Neuroscience, Fondazione Istituto Italiano di Tecnologia (IIT) - Center for Genomic Science, Columbia University - Center for Motor Neuron Biology and Disease and Independent
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RNA metabolism, methyltransferase-like 3 (METTL3), N6-methyladenosine (m6A), RNA epigenetics, motor neurons, age-related neurodegeneration, Transactive response DNAbinding protein-43 (TDP-43), Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (TDP)