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Tommaso Leonardi

Fondazione Istituto Italiano di Tecnologia (IIT) - Center for Genomic Science

SCHOLARLY PAPERS

3

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135

TOTAL CITATIONS

1

Scholarly Papers (3)

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1.

Increased Cholesterol Synthesis Drivesneurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis

Number of pages: 55 Posted: 23 Feb 2024
Rosana-Bristena Ionescu, Alexandra Nicaise, Julie A. Reisz, Eleanor Williams, Pranathi Prasad, Monika Dzieciatkowska, Daniel Stephenson, Marta Suarez Cubero, Liviu Pirvan, Cory Willis, Luca Peruzzotti-Jametti, Valentina Fossati, Frank Edenhofder, Tommaso Leonardi, Christian Frezza, Irina Mohorianu, Angelo D’Alessandro and Stefano Pluchino
University of Cambridge, University of Cambridge, University of Colorado, Aurora - Department of Biochemistry and Molecular Genetics, University of Cambridge, University of Cambridge, University of Colorado, Aurora - Department of Biochemistry and Molecular Genetics, University of Colorado, Aurora - Department of Biochemistry and Molecular Genetics, University of Innsbruck, University of Cambridge, University of Cambridge, University of Cambridge, The New York Stem Cell Foundation Research Institute, University of Innsbruck, Fondazione Istituto Italiano di Tecnologia (IIT) - Center for Genomic Science, University of Cologne - Faculty of Medicine, University of Cambridge - Wellcome Trust and MRC Cambridge Stem Cell Institute, University of Colorado, Aurora - Department of Biochemistry and Molecular Genetics and University of Cambridge
Downloads 49 (1,074,648)
Citation 1

Abstract:

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Neuroimmunology, multiple sclerosis, neural stem cells, cellular senescence, cholesterol metabolism, lipid droplets, multi-omics, SASP, neurotoxicity, disease modelling.

2.

Depletion of Mettl3 in Cholinergic Neurons Causes Adult-Onset Neuromuscular Degeneration

Number of pages: 48 Posted: 08 May 2023
Georgia Dermentzaki, Mattia Furlan, Iris Tanaka, Tommaso Leonardi, Patricia M.S. Passos, Alliny Bastos, Yuna Ayala, Jacob H. Hanna, Serge Przedborski, Dario Bonanomi, Mattia Pelizzola, Francesco Lotti and Sneak Peek Administrator
Columbia University - Center for Motor Neuron Biology and Disease, Fondazione Istituto Italiano di Tecnologia (IIT) - Center for Genomic Science, Fondazione Istituto Italiano di Tecnologia (IIT) - Center for Genomic Science, Fondazione Istituto Italiano di Tecnologia (IIT) - Center for Genomic Science, Saint Louis University - Department of Biochemistry and Molecular Biology, Saint Louis University - Department of Biochemistry and Molecular Biology, Saint Louis University - Department of Biochemistry and Molecular Biology, Weizmann Institute of Science - Department of Molecular Genetics, Columbia University - Center for Motor Neuron Biology and Disease, Università Vita-Salute San Raffaele - Division of Neuroscience, Fondazione Istituto Italiano di Tecnologia (IIT) - Center for Genomic Science, Columbia University - Center for Motor Neuron Biology and Disease and Independent
Downloads 45 (1,121,190)

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RNA metabolism, methyltransferase-like 3 (METTL3), N6-methyladenosine (m6A), RNA epigenetics, motor neurons, age-related neurodegeneration, Transactive response DNAbinding protein-43 (TDP-43), Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (TDP)

3.

Integrative Single-Cell Analysis of Neural Stem/Progenitor Cells Reveals Epigenetically Dysregulated Interferon Response in Progressive Multiple Sclerosis

Number of pages: 58 Posted: 22 Mar 2024
Bongsoo Park, Alexandra Nicaise, Dimitrios Tsitsipatis, Liviu Pirvan, Pranathi Prasad, Miguel Larraz Lopez De Novales, Julia Whitten, Luka Culig, Joseph Llewellyn, Rosana-Bristena Ionescu, Cory Willis, Grzegorz Krzak, Jinshui Fan, Supriyo De, Marta Suarez Cubero, Angeliki Spathopoulou, Luca Peruzzotti-Jametti, Tommaso Leonardi, Frank Edenhofder, Myriam Gorospe, Irina Mohorianu, Stefano Pluchino and Isabel Beerman
Government of the United States of America - National Institute on Aging (NIA), University of Cambridge, Government of the United States of America - Laboratory of Genetics and Genomics, University of Cambridge, University of Cambridge, University of Cambridge, Government of the United States of America - National Institute on Aging (NIA), Government of the United States of America - National Institute on Aging (NIA), Government of the United States of America - National Institute on Aging (NIA), University of Cambridge, University of Cambridge, University of Cambridge, Government of the United States of America - Laboratory of Genetics and Genomics, Government of the United States of America - National Institute on Aging (NIA), University of Innsbruck, University of Innsbruck, University of Cambridge, Fondazione Istituto Italiano di Tecnologia (IIT) - Center for Genomic Science, University of Innsbruck, Government of the United States of America - Laboratory of Genetics and Genomics, University of Cambridge - Wellcome Trust and MRC Cambridge Stem Cell Institute, University of Cambridge and Government of the United States of America - National Institute on Aging (NIA)
Downloads 41 (1,170,409)

Abstract:

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Neural stem/progenitor cells, radial glia, single cell/nucleus multiomics, direct reprogramming, RNA sequencing, DNA methylation, senescence, interferon, epigenetics, progressive multiple sclerosis.