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José Brea

Universidade de Santiago de Compostela

Spain

  • Universidade de Santiago de Compostela

SCHOLARLY PAPERS

3

DOWNLOADS

187

TOTAL CITATIONS

0

Scholarly Papers (3)

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1.

N-Dibenzofuranylmethyl-Substituted 4-Bromo-2,5-Dimethoxyphenethylamines as 5-HT2 Receptor Partial Agonists

Number of pages: 13 Posted: 20 Jul 2023
Breno Almeida Soares, Thirumal Yempala, Darío Martínez-Afani, Williams Acevedo-Fuentes, José Brea, María Isabel Loza, Marta Cimadevila and Bruce Kennedy Cassels
University of Chile, University of Chile, University of Chile, University of Chile, Universidade de Santiago de Compostela, Universidade de Santiago de Compostela, Universidade de Santiago de Compostela and University of Chile
Downloads 110 (640,165)

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phenethylamine derivatives, bulky dibenzofuryl N-substituents, 5-HT2 receptor binding, 5-HT2 receptor agonism, docking orientation

2.

Structure-Based Virtual Screening, In Vitro and In Silico Analysis Identified Novel Potent m6A Demethylase FTO Inhibitors as Promising Neurotherapeutic Agents

Number of pages: 54 Posted: 04 Apr 2026
Alba Irisarri, Aina Bellver-Sanchís, Bhanwar Singh Choudhary, Ana mallo abreu, Luis labrador, Gemma Casadesus, Abhisek Jana, Deb Ranjan Banerjee, Isabel Iriepa, María Isabel Loza, José Brea, Cristina Val, Mercè Pallàs, Diego Muñoz-Torrero and Christian Griñán-Ferré
University of Barcelona, University of Barcelona - Department of Pharmacology and Therapeutic Chemistry, Central University of Rajasthan, University of Barcelona, University of Florida, University of Florida, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Universidade de Santiago de Compostela, Universidade de Santiago de Compostela, affiliation not provided to SSRN, University of Barcelona - Department of Pharmacology and Therapeutic Chemistry, University of Barcelona and University of Barcelona - Department of Pharmacology and Therapeutic Chemistry
Downloads 52 (1,097,529)

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epigenetics, m6A, FTO inhibitors, hit identification, neurodegeneration, SAMP8

3.

Exploring Trisubstituted Adenine Derivatives as Adenosine A1 Receptor Ligands with Antagonist Activity: Synthesis, Biological Evaluation and Molecular Modelling

Number of pages: 50 Posted: 06 Feb 2025
Laura B. Córdoba-Gómez, Álvaro Lorente-Macías, María Isabel Loza, José Brea, Antón Leandro Martínez, Jonathon Mok, Ben King, Francisco Franco-Montalban, Antonio González García, Juan Jose Guardia-Monteagudo, Maria Matos, Asier Unciti-Broceta, Juan Jose Diaz-Mochon and María J. Pineda de las Infantas
University of Granada, affiliation not provided to SSRN, Universidade de Santiago de Compostela, Universidade de Santiago de Compostela, Universidade de Santiago de Compostela, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Granada - Campus La Cartuja, affiliation not provided to SSRN, S.L. Parque Tecnológico de la Salud, Universidade de Santiago de Compostela, affiliation not provided to SSRN, S.L. Parque Tecnológico de la Salud and University of Granada
Downloads 25 (1,385,945)

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Adenine scaffold, docking simulation, cancer cell lines, antiproliferation, orthosteric binding site, selectivity index, pharmacokinetic properties