University of Liverpool - Liverpool Head and Neck Cancer Centre, University of Liverpool - Institute of Systems, Molecular and Integrative Biology, University of Liverpool - Department of Health Data Science, University of Liverpool - Institute of Systems, Molecular and Integrative Biology, University of Liverpool - Institute of Systems, Molecular and Integrative Biology, Liverpool University Hospitals NHS Foundation Trust - Department of Clinical Biochemistry and Metabolic Medicine, University of Liverpool - Institute of Life Course and Medical Sciences, University of Liverpool - Institute of Systems, Molecular and Integrative Biology, Lancaster University - Lancaster Medical School, University of Liverpool - Liverpool Head and Neck Cancer Centre, University of Sheffield - Department of Oncology & Metabolism, Stellenbosch University - Department of Physiological Sciences, University of Liverpool - Palliative Care Unit, Liverpool University Hospitals NHS Foundation Trust - Academic Palliative & End of Life Care Department and University of Liverpool - Institute of Systems, Molecular and Integrative Biology