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Tomáš Otava

Academy of Sciences of the Czech Republic - Institute of Organic Chemistry and Biochemistry

SCHOLARLY PAPERS

2

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Scholarly Papers (2)

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1.

Vinylphosphonate-Based Cyclic Dinucleotides Enhance Sting-Mediated Cancer Immunotherapy

Number of pages: 33 Posted: 11 Jul 2023
Milan Dejmek, Andrea Brazdova, Tomáš Otava, Marketa Pimkova Polidarova, Martin Klíma, Miroslav Smola, Zdenek Vavrina, Miloš Buděšínský, Martin Dračínský, Radek Liboska, Evzen Boura, Gabriel Birkus and Radim Nencka
Academy of Sciences of the Czech Republic - Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic - Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic - Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic - Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic - Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic - Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic - Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic - Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic - Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic - Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic - Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic - Institute of Organic Chemistry and Biochemistry and Academy of Sciences of the Czech Republic - Institute of Organic Chemistry and Biochemistry
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cyclic dinucleotides, STING, cancer, intratumoral administration, immunotherapy

2.

Exploring Advanced Methodologies for NS5 Methyltransferase Targeted Drug Discovery

Number of pages: 26 Posted: 06 Sep 2025
Tomáš Otava, Matúš Drexler, Petra Krafčíková, Dominika Chalupská, Karel Chalupsky, Václav Veverka, Evzen Boura and Radim Nencka
Academy of Sciences of the Czech Republic - Institute of Organic Chemistry and Biochemistry, affiliation not provided to SSRN, affiliation not provided to SSRN, Czech Academy of Sciences, Academy of Sciences of the Czech Republic - Institute of Organic Chemistry and Biochemistry, affiliation not provided to SSRN, Czech Academy of Sciences and Academy of Sciences of the Czech Republic - Institute of Organic Chemistry and Biochemistry
Downloads 27 (1,359,097)

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Dengue virus NS5 methyltransferase, S-adenosylhomocysteine analogs, fluorescence polarization, NMR titration, Echo® mass spectrometry assay, X-ray crystallography, antiviral drug discovery, methyltransferase inhibitors