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Kobayashi Shintaro

affiliation not provided to SSRN

  • affiliation not provided to SSRN

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Mechanistic Insights: Harnessing Ceramic Hydroxyapatite as an Effective Polishing Strategy to Remove Product- and Process-Related Impurities in Bispecific Antibody Purification

Number of pages: 24 Posted: 29 Aug 2023
Nattha Ingavat, Xinhui Wang, Jia Min Liew, Farouq Bin Mahfut, Ka Pui But, Yee Jiun Kok, Xuezhi Bi, Yuansheng Yang, Kobayashi Shintaro, Maria Tsoumpra and Wei Zhang
Agency for Science, Technology and Research (A*STAR) - Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR) - Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR) - Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR) - Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR) - Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR) - Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR) - Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR) - Bioprocessing Technology Institute, affiliation not provided to SSRN, affiliation not provided to SSRN and Agency for Science, Technology and Research (A*STAR) - Bioprocessing Technology Institute
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Abstract:

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bispecific antibody, ceramic hydroxyapatite (CHT) chromatography, C-site cooperation, product- and process-related impurity removal, chromatography-induced aggregation