Author Page for Christophe Pannecouque

In Situ Click Chemistry-Based Discovery of 1,2,3-Triazole-Derived Diarylpyrimidines as Novel HIV-1 NNRTIS by Exploiting the Tolerant Region I in Binding Pocket

Number of pages: 32 Posted: 19 Sep 2023

Yanying Sun, Da Feng, Zhenzhen Zhou, Tao Zhang, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan and Xinyong Liu

Shandong University, Shandong University, Shandong University, Shandong University, Fudan University, KU Leuven - Rega Institute for Medical Research, Shandong University, Shandong University and Shandong University

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Abstract:

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Structure-Based Design of Novel 2,4,5-Trisubstituted Pyrimidine Derivatives as Potent Hiv-1 Nnrtis by Exploiting the Tolerant Regions in Nntris Binding Pocket

Number of pages: 27 Posted: 08 Jan 2025

Zhenzhen Zhou, Minghui Xie, Zongji Zhuo, Sining Tao, Zhening Liang, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Dongwei Kang and Xinyong Liu

Shandong University, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Fudan University, KU Leuven - Rega Institute for Medical Research, Shandong University, Shandong University and Shandong University

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Abstract:

3.

Rational design of dual-site NNRTIs based on 2,4,5-trisubstituted pyrimidine scaffold for potent inhibition of resistant HIV-1

Number of pages: 23 Posted: 18 Jun 2026

Xiangkai Ji, Xiangyi Jiang, Heng Gao, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan and Xinyong Liu

Shandong University, Shandong University, Shandong University, Fudan University, KU Leuven - Rega Institute for Medical Research, Shandong University, Shandong University and Shandong University

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Christophe Pannecouque

Rega Institute for Medical Research

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Scholarly Papers (3)

In Situ Click Chemistry-Based Discovery of 1,2,3-Triazole-Derived Diarylpyrimidines as Novel HIV-1 NNRTIS by Exploiting the Tolerant Region I in Binding Pocket

Abstract:

Structure-Based Design of Novel 2,4,5-Trisubstituted Pyrimidine Derivatives as Potent Hiv-1 Nnrtis by Exploiting the Tolerant Regions in Nntris Binding Pocket

Abstract:

Rational design of dual-site NNRTIs based on 2,4,5-trisubstituted pyrimidine scaffold for potent inhibition of resistant HIV-1

Abstract: