Author Page for Xinyong Liu

Identification of Ebselen Derivatives as Novel SARS-CoV-2 Main Protease Inhibitors: Design, Synthesis, Biological Evaluation, and Structure-Activity Relationships Exploration

Number of pages: 30 Posted: 30 Aug 2023

Heng Zhang, Jing Li, Karoly Toth, Ann E. Tollefson, Lanlan Jing, Shenghua Gao, Xinyong Liu and Peng Zhan

Shandong University, Shandong University, Saint Louis University, Saint Louis University School of Medicine, Shandong University, Shandong University, Shandong University and Shandong University

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Abstract:

2.

Design and Synthesis of Novel Diarylpyrimidine Derivatives as Hiv-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Improved Potency and Metabolic Stability

Number of pages: 46 Posted: 16 Oct 2024

Xinyong Liu, Hao Lin, Da Feng, Jie Guo, Xiangyi Jiang, Yanying Sun, Xiangkai Ji, Erik De Clercq, Christophe Pannecouque, Chin-ho Chen, Dongwei Kang and Peng Zhan

Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, KU Leuven, Fudan University, Duke University, Shandong University and Shandong University

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Abstract:

3.

In Situ Click Chemistry-Based Discovery of 1,2,3-Triazole-Derived Diarylpyrimidines as Novel HIV-1 NNRTIS by Exploiting the Tolerant Region I in Binding Pocket

Number of pages: 32 Posted: 19 Sep 2023

Yanying Sun, Da Feng, Zhenzhen Zhou, Tao Zhang, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan and Xinyong Liu

Shandong University, Shandong University, Shandong University, Shandong University, Fudan University, KU Leuven - Rega Institute for Medical Research, Shandong University, Shandong University and Shandong University

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Abstract:

4.

Design, Synthesis and Structure-Activity Relationships of Novel HIV Capsid Inhibitors with Potent Antiviral Activities

Number of pages: 58 Posted: 04 Apr 2025

Dazhou Shi, Shujing Xu, Lin Sun, Prem Prakash Sharma, Brijesh Rathi, Mei Wang, Linan Wu, Xiangyi Jiang, Erik De Clercq, Christophe Pannecouque, Xinyong Liu, Alexej Dick and Peng Zhan

Shandong University, Shandong University, Shandong University, University of Delhi, University of Delhi - Laboratory for Translational Chemistry and Drug Discovery, Weifang Medical University, Shandong University, Shandong University, Fudan University, Fudan University, Shandong University, Drexel University - College of Medicine and Shandong University

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Abstract:

5.

Structure-Based Design of Novel 2,4,5-Trisubstituted Pyrimidine Derivatives as Potent Hiv-1 Nnrtis by Exploiting the Tolerant Regions in Nntris Binding Pocket

Number of pages: 27 Posted: 08 Jan 2025

Zhenzhen Zhou, Minghui Xie, Zongji Zhuo, Sining Tao, Zhening Liang, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Dongwei Kang and Xinyong Liu

Shandong University, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Fudan University, KU Leuven - Rega Institute for Medical Research, Shandong University, Shandong University and Shandong University

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Abstract:

6.

Further Exploring the Tolerant Region Ii: Identification of 2,4,5-Trisubstituted Pyrimidines as Hiv-1 Reverse Transcriptase Allosteric Inhibitors with Desirable Antiviral Activities and Reduced Cytotoxicity

Number of pages: 22 Posted: 11 Jun 2025

Zhenzhen Zhou, Lin Zheng, Wenbo Jiang, Wenbo Zhang, Fabao Zhao, Zhening Liang, Erik De De Clercq, Christophe Pannecouque, Peng Zhan, Dongwei Kang and Xinyong Liu

Shandong University, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Fudan University, Shandong University, Shandong University and Shandong University

Downloads 40

Abstract:

7.

Discovery of 2,4,6-Trisubstituted Pyrimidine Derivatives as Novel Potent Hiv-1 Nnrtis by Exploiting the Tolerant Region Ii of the Nnibp

Number of pages: 24 Posted: 12 Jul 2024

Zhenzhen Zhou, Yanying Sun, Yanyang Qin, Na Wang, Fabao Zhao, Zhao Wang, Erik De De Clercq, Christophe Pannecouque, Peng Zhan, Dongwei Kang and Xinyong Liu

Shandong University, Shandong University, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Fudan University, Shandong University, Shandong University and Shandong University

Downloads 40

Citation 1

Abstract:

8.

Design, Synthesis, and Biological Evaluation of Dual-Site Hiv-1 Inhibitors Simultaneously Targeting the Nnrti Binding Pocket and an Adjacent Site with Favorable Resistance Profiles

Number of pages: 23 Posted: 16 Jul 2025

Xiangkai Ji, Xiangyi Jiang, Xing Huang, Heng Gao, Zhen Gao, Ping Gao, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan and Xinyong Liu

Shandong University, Shandong University, Yanbian University, Shandong University, Shandong University, Shandong First Medical University - Shandong Provincial Hospital, Fudan University, Fudan University, Shandong University, Shandong University and Shandong University

Downloads 24

Abstract:

9.

Rational design of dual-site NNRTIs based on 2,4,5-trisubstituted pyrimidine scaffold for potent inhibition of resistant HIV-1

Number of pages: 23 Posted: 18 Jun 2026

Xiangkai Ji, Xiangyi Jiang, Heng Gao, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan and Xinyong Liu

Shandong University, Shandong University, Shandong University, Fudan University, KU Leuven - Rega Institute for Medical Research, Shandong University, Shandong University and Shandong University

Downloads 23

Xinyong Liu

Shandong University

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Scholarly Papers (9)

Identification of Ebselen Derivatives as Novel SARS-CoV-2 Main Protease Inhibitors: Design, Synthesis, Biological Evaluation, and Structure-Activity Relationships Exploration

Abstract:

Design and Synthesis of Novel Diarylpyrimidine Derivatives as Hiv-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Improved Potency and Metabolic Stability

Abstract:

In Situ Click Chemistry-Based Discovery of 1,2,3-Triazole-Derived Diarylpyrimidines as Novel HIV-1 NNRTIS by Exploiting the Tolerant Region I in Binding Pocket

Abstract:

Design, Synthesis and Structure-Activity Relationships of Novel HIV Capsid Inhibitors with Potent Antiviral Activities

Abstract:

Structure-Based Design of Novel 2,4,5-Trisubstituted Pyrimidine Derivatives as Potent Hiv-1 Nnrtis by Exploiting the Tolerant Regions in Nntris Binding Pocket

Abstract:

Further Exploring the Tolerant Region Ii: Identification of 2,4,5-Trisubstituted Pyrimidines as Hiv-1 Reverse Transcriptase Allosteric Inhibitors with Desirable Antiviral Activities and Reduced Cytotoxicity

Abstract:

Discovery of 2,4,6-Trisubstituted Pyrimidine Derivatives as Novel Potent Hiv-1 Nnrtis by Exploiting the Tolerant Region Ii of the Nnibp

Abstract:

Design, Synthesis, and Biological Evaluation of Dual-Site Hiv-1 Inhibitors Simultaneously Targeting the Nnrti Binding Pocket and an Adjacent Site with Favorable Resistance Profiles

Abstract:

Rational design of dual-site NNRTIs based on 2,4,5-trisubstituted pyrimidine scaffold for potent inhibition of resistant HIV-1

Abstract: