Government of the United Kingdom - Oxford University Hospitals NHS Foundation Trust, University of Oxford, University of Oxford, University of Cambridge - Department of Oncology, University College London - UCL Cancer Institute, Manchester Academic Health Sciences Centre - The Christie NHS Foundation Trust, Government of the United Kingdom - Oxford University Hospitals NHS Foundation Trust, University of Oxford - Nuffield Department of Primary Care Health Sciences, University of Oxford, University of Oxford, Velindre Cancer Centre, University Hospitals Bristol - University Hospitals Bristol and Weston NHS Foundation Trust, Imperial College London - Hammersmith Hospital, Department of Cancer Medicine, University of Cambridge, NHS Foundation Trust - Norfolk and Norwich University Hospital, Government of the United Kingdom - Hull University Teaching Hospitals NHS Trust, Coventry University - Coventry University Hospital, Cardiff University - Centre for Trials Research, University of Leeds - Institute of Medical Research, University of Oxford - MRC Oxford Institute for Radiation Oncology, University College London - Department of Medical Physics and Biomedical Engineering and University of Cambridge