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Krijn K. Djikstra

The Francis Crick Institute

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Pharmacologic Inhibition of Nonsense-Mediated Decay Induces Anti-Tumour Immunogenicity in Ex Vivo Patient Tumours

Number of pages: 65 Posted: 16 Feb 2024
University College London - UCL Cancer Institute, University College London - UCL Cancer Institute, University College London - UCL Cancer Institute, University College London - UCL Cancer Institute, University College London - UCL Cancer Institute, University College London - UCL Cancer Institute, Weizmann Institute of Science, Weizmann Institute of Science, University College London - UCL Cancer Institute, University College London - UCL Cancer Institute, Genesis Therapeutics, Inc., University College London - Cancer Immunology Unit, University College London - UCL Cancer Institute, University College London - UCL Cancer Institute, University College London - UCL Cancer Institute, University College London - UCL Cancer Institute, University College London - Research Department of Hematology, University College London - UCL Cancer Institute, University College London - UCL Cancer Institute, The Francis Crick Institute, The Hebrew University of Jerusalem, University College London - UCL Cancer Institute, Independent, The Francis Crick Institute, Genesis Therapeutics, Inc., University College London - Cancer Immunology Unit, University College London - UCL Cancer Institute, Weizmann Institute of Science, The Francis Crick Institute - Cancer Evolution and Genome Instability Laboratory, University College London - UCL Cancer Institute and Independent
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Abstract:

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Nonsense-mediated decay, SMG1, cancer, anti-tumour immunogenicity, neoantigens, frameshift insertions/deletions, patient-derived fragments.