Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, affiliation not provided to SSRN, affiliation not provided to SSRN, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research and affiliation not provided to SSRN