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Jia Li

Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research

52 Sanlihe Rd.

Datun Road, Anwai

Beijing, Xicheng District 100864

China

  • Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research

SCHOLARLY PAPERS

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Scholarly Papers (11)

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1.

Exploring the Mechanism of the PTP1B Inhibitors by Molecular Dynamics and Experimental Study

Downloads 135 (547,695)

Exploring the Mechanism of the PTP1B Inhibitors by Molecular Dynamics and Experimental Study

Number of pages: 30 Posted: 01 Jul 2023
Tian-Tian Zhao, Hao-Jie Hu, Lixin Gao, Yubo Zhou, Yun-Long Zhu, Chun Zhang, Jia Li and Wen-Long Wang
Jiangnan University, Jiangnan University, Jiangnan University, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Jiangnan University, Jiangnan University, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research and Jiangnan University
Downloads 76 (848,302)

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Protein tyrosine phosphatases inhibitors, PTP1B inhibitors, Mechanism study, molecular dynamics

Exploring the Mechanism of the PTP1B Inhibitors by Molecular Dynamics and Experimental Study

Number of pages: 30 Posted: 20 Jun 2023
Tian-Tian Zhao, Hao-Jie Hu, Lixin Gao, Yubo Zhou, Yun-Long Zhu, Chun Zhang, Jia Li and Wen-Long Wang
Jiangnan University, Jiangnan University, Jiangnan University, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Jiangnan University, Jiangnan University, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research and Jiangnan University
Downloads 59 (996,491)

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Protein tyrosine phosphatases inhibitors, PTP1B inhibitors, Mechanism study, Molecular dynamics

2.

Structure-Based Rational Design Enables Discovery of a New Selective and Potent Akt Degrader with Improved Dermatologic Safety

Number of pages: 32 Posted: 14 Mar 2022
Cheng-Liang Zhu, Xiaomin Luo, Tian Tian, Zijian Rao, Hanlin Wang, Zhesheng Zhou, Zizheng Gao, Tian Mi, Danni Chen, Yongjin Xu, Yizhe Wu, Jinxin Che, Peihua Luo, Yubo Zhou, Jia Li and Xiaowu Dong
Zhejiang University, Beijing University of Chinese Medicine - School of Chinese Material Medica, Zhejiang University, Zhejiang University, Fudan University, Zhejiang University, Zhejiang University, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Zhejiang University, Chinese Academy of Sciences (CAS) - Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Zhejiang University, Zhejiang University, Zhejiang University, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research and Zhejiang University
Downloads 102 (684,672)

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AKT, Protein kinase B, PROTAC, Chemical degrader, rational design, Cutaneous toxicity

3.

Novel Imidazo[1,2,4] Triazole Derivatives: Synthesis, Fluorescence, Bioactivity for SHP1

Number of pages: 32 Posted: 13 Oct 2023
Xue Yan, Chun Zhang, Lixin Gao, Min-Min Liu, Yu-Ting Yang, Li-Jie Yu, Yubo Zhou, Slieman Milaneh, Yun-Long Zhu, Jia Li and Wen-Long Wang
Jiangnan University, Jiangnan University, Jiangnan University, Jiangnan University, Jiangnan University, Jiangnan University, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Jiangnan University, Jiangnan University, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research and Jiangnan University
Downloads 78 (837,727)

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Imidazo[1, 2, 4] triazole derivatives, Fluorescence property, SHP1, Bioactivity, Cellular imaging

4.

Development of Novel Epoxyketone Macrocyclic Peptidyl Proteasome Inhibitors Through Opa-Mediated One-Step Cyclization of Unprotected Peptides

Number of pages: 54 Posted: 08 Jan 2025
Jiankang Zhang, Gongruixue Zeng, Gaoya Xu, Lixin Gao, Xiaoli Zheng, Xinglong Chi, Zheyuan Shen, Yu Cao, Jianjun Xi, Jinxin Che, Xiaowu Dong, Yaoli Shi, Jiayi Ma, Chong Zhang, Linghui Zeng, Huajian Zhu, Jiaan Shao, Yubo Zhou and Jia Li
Hangzhou City University, Hangzhou City University, affiliation not provided to SSRN, Jiangnan University, Hangzhou City University, Hangzhou Medical College, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Zhejiang University, Zhejiang University, Hangzhou City University, Hangzhou City University, Hangzhou City University, Hangzhou City University, Hangzhou City University, Hangzhou City University, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research and Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research
Downloads 70 (899,324)

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Proteasome inhibitors, Macrocycle, Stability, Anti-cancer activities

5.

Discovery of Novel Cdk9 Inhibitor with Tridentate Ligand: Design, Synthesis and Biological Evaluation

Number of pages: 28 Posted: 15 May 2024
Yang Liu, Ye Zhong, Jing Xu, Shaoyue Ding, Huiying Cao, Yufei Zhang, Baichun Hu, Shucheng Han, Huali Yang, Maosheng Cheng, Jia Li and Yili Sun
Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, affiliation not provided to SSRN, affiliation not provided to SSRN, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research and affiliation not provided to SSRN
Downloads 55 (1,020,567)

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CDK9, inhibitor, colorectal cancer, apoptosis, tridentate ligand

6.

Development of Coumarin and Procaine Linked Hybrid Molecules as a Novel Class of Shp1 Fluorescent Activators

Number of pages: 19 Posted: 16 Jan 2025
Xu-Yang Mu, Lixin Gao, Zhen-Xuan Zhang, Zi-Tong Cao, Qing Cao, Chun Zhang, Jia Li, Da-Jun Xiang, Yubo Zhou and Wen-Long Wang
Jiangnan University, Jiangnan University, Jiangnan University, affiliation not provided to SSRN, Jiangnan University, Jiangnan University, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, affiliation not provided to SSRN, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research and Jiangnan University
Downloads 46 (1,121,190)

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Coumarin-procaine hybrid molecules, SHP1, Cellular imaging, Fluorescent organic molecules, Selectivity for SHP1 homologous proteins

7.

The Deubiquitinase Usp2 Preserves Intestinal Barrier Through the Traf6/Nf-Κb/Mlck/Mlc Signaling in Ulcerative Colitis

Number of pages: 28 Posted: 10 Jan 2025
Ruochen Zhou, Yuanyuan Cui, Weihao Wang, Yidan Qu, Gaojie Zhang, Xue Wang, Yili Sun and Jia Li
affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN and Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research
Downloads 46 (1,133,231)

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ubiquitin-specific protease 2, ulcerative colitis, intestinal epithelial cell, Tight junction

8.

Pentacyclic Triterpenoids as Potential Acl Inhibitors from the Rare Medicinal Plant Semiliquidambar Cathayensis

Number of pages: 34 Posted: 28 Mar 2024
Yu-Fei Wu, Ze-Yu Zhao, Min-Jie Yang, Yu-Hang He, Yi Zang, Jia Li, Jin-Feng Hu and Juan Xiong
affiliation not provided to SSRN, Taizhou University, affiliation not provided to SSRN, affiliation not provided to SSRN, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Taizhou University and Fudan University
Downloads 45 (1,133,231)

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Semiliquidambar cathayensis, triterpenoids, Semiliquidacids, ACL (ATP-citrate lyase) inhibitor, molecular docking

9.

AMPK-Mediated Phosphorylation on 53BP1 Promotes NHEJ

Number of pages: 42 Posted: 22 May 2020
Yuejing Jiang, Ying Dong, Yifeng Luo, Shangwen Jiang, Fei-Long Meng, Minjia Tan, Yi Zang and Jia Li
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research and Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research
Downloads 34 (1,277,121)

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AMPK, phosphorylation, 53BP1, DNA double-strand break repair, genomic stability

10.

Phytochemical profiling of Manglietia chevalieri and its potential in attenuating pulmonary fibrosis: Insights into bioactive constituents

Number of pages: 57 Posted: 29 Apr 2026
Zi‐Jie Long, Mao-Mao Zheng, Yu-Hang He, Bi-Xi Tang, Zhi-Xuan Wang, Xian-Neng Lu, Xi Chen, Jia Li, Yi Zang and Juan Xiong
affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Lin Gang Laboratory, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, affiliation not provided to SSRN and Fudan University
Downloads 33 (1,436,435)

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Manglietia chevalieri, Magnoliaceae, Manglianins, Anti-inflammation, Anti-fibrotic activity

11.

DOT1L-Mediated H3K79 Methylation Regulates Thermogenic Adipocyte Differentiation and Function

Number of pages: 36 Posted: 23 Jun 2020
Lin Shuai, Bo-Han Li, Haowen Jiang, Ya-Nan Duan, Lin Yang, Jia Li and Jing-Ya Li
Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research and Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research
Downloads 31 (1,318,317)

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Brown and beige adipocytes, epigenetic regulator, adipogenesis, thermogenesis, Obesity