Author Page for Xiaowu Dong

Structure-Based Rational Design Enables Discovery of a New Selective and Potent Akt Degrader with Improved Dermatologic Safety

Number of pages: 32 Posted: 14 Mar 2022

Cheng-Liang Zhu, Xiaomin Luo, Tian Tian, Zijian Rao, Hanlin Wang, Zhesheng Zhou, Zizheng Gao, Tian Mi, Danni Chen, Yongjin Xu, Yizhe Wu, Jinxin Che, Peihua Luo, Yubo Zhou, Jia Li and Xiaowu Dong

Zhejiang University, Beijing University of Chinese Medicine - School of Chinese Material Medica, Zhejiang University, Zhejiang University, Fudan University, Zhejiang University, Zhejiang University, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Zhejiang University, Chinese Academy of Sciences (CAS) - Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Zhejiang University, Zhejiang University, Zhejiang University, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research and Zhejiang University

Downloads 102 (684,672)

Abstract:

2.

Development of Novel Epoxyketone Macrocyclic Peptidyl Proteasome Inhibitors Through Opa-Mediated One-Step Cyclization of Unprotected Peptides

Number of pages: 54 Posted: 08 Jan 2025

Jiankang Zhang, Gongruixue Zeng, Gaoya Xu, Lixin Gao, Xiaoli Zheng, Xinglong Chi, Zheyuan Shen, Yu Cao, Jianjun Xi, Jinxin Che, Xiaowu Dong, Yaoli Shi, Jiayi Ma, Chong Zhang, Linghui Zeng, Huajian Zhu, Jiaan Shao, Yubo Zhou and Jia Li

Hangzhou City University, Hangzhou City University, affiliation not provided to SSRN, Jiangnan University, Hangzhou City University, Hangzhou Medical College, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Zhejiang University, Zhejiang University, Hangzhou City University, Hangzhou City University, Hangzhou City University, Hangzhou City University, Hangzhou City University, Hangzhou City University, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research and Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research

Downloads 70 (899,324)

Abstract:

3.

Discovery and Characterization of Novel Fgfr1 Inhibitors in Triple-Negative Breast Cancer Via Hybrid Virtual Screening and Molecular Dynamics Simulations

Number of pages: 57 Posted: 09 May 2024

Yuchen Wang, Zheyuan Shen, Ronfen Chen, Xinglong Chi, Wenjie Li, Donghang Xu, Yan Lu, Jianjun Ding, Xiaowu Dong and Xiaoli Zheng

affiliation not provided to SSRN, affiliation not provided to SSRN, Zhejiang University, Hangzhou Medical College, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Zhejiang University and affiliation not provided to SSRN

Downloads 60 (1,000,027)

Abstract:

4.

A Practical 'Pretacs-Cytoblot' Platform Accelerates the Streamlined Development of Protac-Based Protein Degraders

Number of pages: 35 Posted: 23 Jan 2023

Zijian Rao, Kailin Li, Ju Hong, Danni Chen, Baoli Ding, Li Jiang, Xuxin Qi, Bo Yang, Qiaojun He, Xiaowu Dong, Ji Cao and Cheng-Liang Zhu

Zhejiang University, Zhejiang University, Zhejiang University, Zhejiang University, Zhejiang University, Zhejiang University, Zhejiang University, Zhejiang University, Zhejiang University, Zhejiang University, Zhejiang University and Zhejiang University

Downloads 47 (1,097,529)

Xiaowu Dong

Zhejiang University

4

279

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Scholarly Papers (4)

Structure-Based Rational Design Enables Discovery of a New Selective and Potent Akt Degrader with Improved Dermatologic Safety

Abstract:

Development of Novel Epoxyketone Macrocyclic Peptidyl Proteasome Inhibitors Through Opa-Mediated One-Step Cyclization of Unprotected Peptides

Abstract:

Discovery and Characterization of Novel Fgfr1 Inhibitors in Triple-Negative Breast Cancer Via Hybrid Virtual Screening and Molecular Dynamics Simulations

Abstract:

A Practical 'Pretacs-Cytoblot' Platform Accelerates the Streamlined Development of Protac-Based Protein Degraders

Abstract: