affiliation not provided to SSRN, University of Oxford, The University of Manchester - Faculty of Biology, Medicine and Health, The University of Manchester, The University of Manchester, Medical College of Wisconsin, University of Montpellier - Institut régional du Cancer de Montpellier, CHU Nimes, German Cancer Research Center (DKFZ), The University of Manchester - Translational Radiobiology Group, University of Cambridge - Department of Oncology, KU Leuven, Fondazione IRCCS Istituto Nazionale dei Tumori, Maastricht University, German Cancer Research Center (DKFZ), University of Heidelberg, University of Leicester, affiliation not provided to SSRN, Ghent University, University of Leicester, affiliation not provided to SSRN, The University of Manchester - Translational Radiobiology Group, The University of Manchester, The University of Manchester, Fondazione IRCCS Istituto Nazionale dei Tumori and Fondazione IRCCS Istituto Nazionale dei Tumori