Government of the United States of America - Division of Cancer Epidemiology and Genetics, Government of the United States of America - Division of Cancer Epidemiology and Genetics, Memorial Sloan Kettering Cancer Center - Department of Epidemiology and Biostatistics, Peace and Love Hospital, Komfo Anokye Teaching Hospital, Korle Bu Teaching Hospital, Korle Bu Teaching Hospital, Komfo Anokye Teaching Hospital, Korle Bu Teaching Hospital, Komfo Anokye Teaching Hospital, Korle Bu Teaching Hospital, Komfo Anokye Teaching Hospital, Komfo Anokye Teaching Hospital, University of Calgary - Department of Pathology and Laboratory Medicine, Government of the United States of America - Division of Cancer Epidemiology and Genetics, University of Cambridge - Department of Oncology, University of Cambridge - Department of Oncology, University of Cambridge - Department of Oncology, Government of the United States of America - Division of Cancer Epidemiology and Genetics, Government of the United States of America - Division of Cancer Epidemiology and Genetics, Government of the United States of America - Frederick National Laboratory for Cancer Research, Government of the United States of America - Frederick National Laboratory for Cancer Research, The John Hopkins Hospital - Department of Biostatistics, University of Ghana, University of Ghana Medical School, University of Ghana, Loma Linda University, Komfo Anokye Teaching Hospital, University of Cambridge - Department of Public Health and Primary Care, University of Edinburgh - Institute of Genetics and Cancer, Government of the United States of America - Division of Cancer Epidemiology and Genetics and Independent

affiliation not provided to SSRN, affiliation not provided to SSRN, Vall d'Hebron Institute of Oncology (VHIO), affiliation not provided to SSRN, Universidade de Santiago de Compostela - Health Research Institute of Santiago de Compostela (IDIS), affiliation not provided to SSRN, University of Montpellier - Institut régional du Cancer de Montpellier, UZ Leuven, affiliation not provided to SSRN, Ghent University, German Cancer Research Center (DKFZ), Fondazione IRCCS Istituto Nazionale dei Tumori, University of Cambridge - Department of Oncology, affiliation not provided to SSRN, affiliation not provided to SSRN, CHU Nimes, Fondazione IRCCS Istituto Nazionale dei Tumori, affiliation not provided to SSRN, affiliation not provided to SSRN, UZ Gasthuisberg - Department of Radiation Oncology, affiliation not provided to SSRN, Ghent University, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Leicester, affiliation not provided to SSRN, Maastricht University, affiliation not provided to SSRN, German Cancer Research Center (DKFZ), University of Heidelberg, University of Leicester, affiliation not provided to SSRN, affiliation not provided to SSRN, Ghent University, affiliation not provided to SSRN, University of Leicester, UZ Leuven, Polytechnic University of Milan, University of Leicester, The University of Manchester - Translational Radiobiology Group, affiliation not provided to SSRN and affiliation not provided to SSRN

affiliation not provided to SSRN, University of Oxford, The University of Manchester - Faculty of Biology, Medicine and Health, The University of Manchester, The University of Manchester, Medical College of Wisconsin, University of Montpellier - Institut régional du Cancer de Montpellier, CHU Nimes, German Cancer Research Center (DKFZ), The University of Manchester - Translational Radiobiology Group, University of Cambridge - Department of Oncology, KU Leuven, Fondazione IRCCS Istituto Nazionale dei Tumori, Maastricht University, German Cancer Research Center (DKFZ), University of Heidelberg, University of Leicester, affiliation not provided to SSRN, Ghent University, University of Leicester, affiliation not provided to SSRN, The University of Manchester - Translational Radiobiology Group, The University of Manchester, The University of Manchester, Fondazione IRCCS Istituto Nazionale dei Tumori and Fondazione IRCCS Istituto Nazionale dei Tumori

affiliation not provided to SSRN, Humanitas University, University of Copenhagen, University of Bologna, University of Copenhagen, affiliation not provided to SSRN, Fondazione IRCCS Istituto Nazionale dei Tumori, Fondazione IRCCS Istituto Nazionale dei Tumori, Government of the United States of America - Division of Cancer Epidemiology and Genetics, University of Toronto, University of Cambridge - Centre for Cancer Genetic Epidemiology, affiliation not provided to SSRN, Pontificia Universidad Javeriana, affiliation not provided to SSRN, Hannover Medical School, University of Cambridge, European Institute of Oncology (IEO) IRCCS, affiliation not provided to SSRN, University of Utah, University of Edinburgh, Hospital Universitario de Santiago, Intermountain Healthcare, affiliation not provided to SSRN, affiliation not provided to SSRN, Karolinska Institutet, University of Cambridge - Centre for Cancer Genetic Epidemiology, affiliation not provided to SSRN, Hannover Medical School, University of Cambridge - Department of Oncology, Karolinska Institutet - Department of Medical Epidemiology and Biostatistics, The University of Manchester - Manchester Centre for Genomic Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, University of Edinburgh, Karolinska Institutet, Hospital Universitario de Santiago, affiliation not provided to SSRN, University of Paris-Saclay - INSERM, CESP, affiliation not provided to SSRN, University of Cologne - Center for Integrated Oncology (CIO), German Cancer Research Center (DKFZ), Hannover Medical School, affiliation not provided to SSRN, Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC), University of Tübingen, The University of Manchester, Peter MacCallum Cancer Centre, Pomeranian Medical University, affiliation not provided to SSRN, Pomeranian Medical University, University of Cambridge - Centre for Cancer Genetic Epidemiology, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Crete - Medical School, Cancer Council Victoria, University of Toronto, The University of Manchester, University Medical Center Hamburg- Eppendorf, The Cyprus Institute of Neurology & Genetics, Nicosia, affiliation not provided to SSRN, Shaukat Khanum Memorial Cancer Hospital and Research Centre, affiliation not provided to SSRN, University of Thessaly, King’s College London, affiliation not provided to SSRN, affiliation not provided to SSRN, Pontificia Universidad Javeriana, Berghofer Medical Research Institute; Faculty of Medicine, The University of Queensland, University of Oxford, University of Paris-Saclay, University of Cambridge - Centre for Cancer Genetic Epidemiology, affiliation not provided to SSRN, Medical College of Wisconsin, Mayo Clinic, Agency for Science, Technology and Research (A*STAR) - Genome Institute of Singapore, affiliation not provided to SSRN, affiliation not provided to SSRN, Mayo Clinic - Department of Pathology, University of Pennsylvania - Perelman School of Medicine, Harvard University, University of Southern California - Department of Preventive Medicine, American Cancer Society, Mayo Clinic, affiliation not provided to SSRN, University of Washington - Department of Epidemiology, affiliation not provided to SSRN, University of Pennsylvania, affiliation not provided to SSRN, National Health Research Institutes - National Institute of Environmental Health Sciences, Mayo Clinic, Boston University, American Cancer Society, Mayo Clinic, National Health Research Institutes - National Institute of Environmental Health Sciences, American Cancer Society, National Health Research Institutes - National Institute of Environmental Health Sciences, affiliation not provided to SSRN, affiliation not provided to SSRN, Mayo Clinic - Mayo Clinic Hospital, affiliation not provided to SSRN, affiliation not provided to SSRN, Charles University and General University Hospital in Prague - Institute of Medical Biochemistry and Laboratory Diagnostics, Charles University, Charles University, Charles University and General University Hospital in Prague - Institute of Medical Biochemistry and Laboratory Diagnostics, Monash University, Monash University, Monash University, Monash University, Monash University, Monash University, University of Melbourne, INSERM, U900, INSERM, U900, Institut Curie, affiliation not provided to SSRN, affiliation not provided to SSRN, Fondazione IRCCS Istituto Nazionale dei Tumori, affiliation not provided to SSRN and affiliation not provided to SSRN

Aarhus University - Aarhus University Hospital, Aarhus University - Aarhus University Hospital, University of Cambridge - Centre for Cancer Genetic Epidemiology, University of Cambridge - Department of Oncology, Wellcome Sanger Institute, University of Cambridge - Department of Oncology, University of Cambridge - Centre for Cancer Genetic Epidemiology, Aarhus University - Aarhus University Hospital, Aarhus University, Aarhus University - Aarhus University Hospital and Aarhus University - Aarhus University Hospital