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Kaikai Lyu

affiliation not provided to SSRN

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SCHOLARLY PAPERS

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Scholarly Papers (1)

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Exploiting Structural Variability in the Kinase Back-Pocket to Modulate Polypharmacology of Tam Inhibitors

Number of pages: 51 Posted: 28 Jan 2025
Megan D. Hopkins, Dehui Zhang, Zhilong Chen, Andrew L. McIver, Justus M. Huelse, Jyoti P. Mahajan, Kaikai Lyu, Michael A. Stashko, Brittany Smith, Tsz Y. Yeung, H. Shelton Earp, Stephen V. Frye, Deborah DeRyckere, Dmitri Kireev, Douglas K. Graham and Xiaodong Wang
affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Emory University - Department of Pediatrics, University of Missouri - Columbia, Emory University - Department of Pediatrics and affiliation not provided to SSRN
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Abstract:

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TAM kinases, MERTK inhibitor, AXL inhibitor, TYRO3 inhibitor, polypharmacology, kinase back-pocket