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Dmitri Kireev

University of Missouri - Columbia

SCHOLARLY PAPERS

3

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205

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0

Scholarly Papers (3)

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1.

Combining Pharmacophore Models Derived from DNA-Encoded Chemical Libraries with Structure-Based Exploration to Predict Tankyrase 1 Inhibitors

Number of pages: 97 Posted: 07 Nov 2022
Alba L. Montoya, Marta Glavatskikh, Brayden J. Halverson, Lik Hang Yuen, Herwig Schüler, Dmitri Kireev and Raphael M. Franzini
University of Utah - Department of Medicinal Chemistry, University of North Carolina (UNC) at Chapel Hill, University of Utah - Department of Medicinal Chemistry, University of Utah - Department of Medicinal Chemistry, Lund University, University of Missouri - Columbia and University of Utah - Department of Medicinal Chemistry
Downloads 116 (613,149)

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DNA-encoded chemical libraries, TNKS1 inhibitors, Pharmacophores, Computer-assisted drug discovery, virtual screening, hit-to-lead development

2.

Exploiting Structural Variability in the Kinase Back-Pocket to Modulate Polypharmacology of Tam Inhibitors

Number of pages: 51 Posted: 28 Jan 2025
Megan D. Hopkins, Dehui Zhang, Zhilong Chen, Andrew L. McIver, Justus M. Huelse, Jyoti P. Mahajan, Kaikai Lyu, Michael A. Stashko, Brittany Smith, Tsz Y. Yeung, H. Shelton Earp, Stephen V. Frye, Deborah DeRyckere, Dmitri Kireev, Douglas K. Graham and Xiaodong Wang
affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Emory University - Department of Pediatrics, University of Missouri - Columbia, Emory University - Department of Pediatrics and affiliation not provided to SSRN
Downloads 46 (1,133,231)

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TAM kinases, MERTK inhibitor, AXL inhibitor, TYRO3 inhibitor, polypharmacology, kinase back-pocket

3.

Identification and optimization of first-in-class RNA helicase inhibitors

Number of pages: 33 Posted: 09 Jan 2026
Xiaowen Wang, Feijun Wang, Deyu Kong, Dilipkumar Uredi, Fengling Li, Feng Li, Jayachandra Rayadurgam, Hanxuan Li, Esther Wolf, U. Hang Chan, Irene Chau, Hong Zeng, Julia Garcia Perez, Derek J. Wilson, Frances M. Bashore, Xiaodong Wang, Levon Halabelian, Kevin J. Frankowski, Dmitri Kireev and Alison Donnelly Axtman
University of Missouri, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Goethe University Frankfurt - Structural Genomics Consortium, Nanjing University of Science and Technology, affiliation not provided to SSRN, affiliation not provided to SSRN, York University, University of Toronto, University of Toronto, University of Toronto, University of Toronto, York University, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Toronto, affiliation not provided to SSRN, University of Missouri - Columbia and University of North Carolina (UNC) at Chapel Hill - Structural Genomics Consortium
Downloads 43 (1,183,237)

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RNA helicases, MDA5, LGP2, DDX1, inhibitor, structure-based virtual screening, hit-to-lead optimization, HDX-MS