University of Missouri, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Goethe University Frankfurt - Structural Genomics Consortium, Nanjing University of Science and Technology, affiliation not provided to SSRN, affiliation not provided to SSRN, York University, University of Toronto, University of Toronto, University of Toronto, University of Toronto, York University, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Toronto, affiliation not provided to SSRN, University of Missouri - Columbia and University of North Carolina (UNC) at Chapel Hill - Structural Genomics Consortium