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Shan Cen

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Rational Design, Synthesis, and Evaluating Primary Biological Activities of Novel Hiv-1 Protease Inhibitors Containing Heteraryl Acetamides as the P2 Ligands

Number of pages: 33 Posted: 05 Jun 2025
Yucheng Wang, Sihan Meng, Yu Gao, Qingqing Yang, Ling Ma, Biao Dong, Juxian Wang, Guoning Zhang, Minghua Wang, Shan Cen, Mei Zhu and Qi Shan
Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC) - Institute of Medicinal Biotechnology, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC) - CAMS Key Laboratory of Antiviral Drug Research, affiliation not provided to SSRN, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC) - Institute of Medicinal Biotechnology, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN and Tianjin Institute of Pharmaceutical Research
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HIV-1 protease inhibitors, phenylacetamide derivatives, enzymatic inhibitory activity, antiviral activity, darunavir-resistant HIV-1 variant