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Krzysztof Rolka

affiliation not provided to SSRN

  • affiliation not provided to SSRN

SCHOLARLY PAPERS

2

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57

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Scholarly Papers (2)

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1.

Conformational Analysis and Structural Characterization of Furin Inhibitors and Their Enzyme Complexes: Structural Insights into the Role of Cis/Trans Isomerization of the P2′–P3′ Peptide Bond

Downloads 33 (1,304,549)

Conformational Analysis and Structural Characterization of Furin Inhibitors and Their Enzyme Complexes: Structural Insights into the Role of Cis/Trans Isomerization of the P2′–P3′ Peptide Bond

Number of pages: 15 Posted: 24 Jan 2026
Dawid Dębowski, Aleksandra Helbik-Maciejewska, Agata Gitlin-Domagalska, Ptaszynska Natalia, Anna Łęgowska, Martyna Maszota-Zieleniak, Sergey A. Samsonov, Igor Zhukov and Krzysztof Rolka
University of Gdansk, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Gdansk, University of Gdansk, affiliation not provided to SSRN and affiliation not provided to SSRN
Downloads 20 (1,525,626)

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Furin inhibitor, NMR spectroscopy, cyclic peptide, molecular modeling

Conformational Analysis and Structural Characterization of Furin Inhibitors and Their Enzyme Complexes: Structural Insights into the Role of Cis/Trans Isomerization of the P2′–P3′ Peptide Bond

Number of pages: 15 Posted: 24 Jan 2026
Dawid Dębowski, Aleksandra Helbik-Maciejewska, Agata Gitlin-Domagalska, Ptaszynska Natalia, Anna Łęgowska, Martyna Maszota-Zieleniak, Sergey A. Samsonov, Igor Zhukov and Krzysztof Rolka
University of Gdansk, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Gdansk, University of Gdansk, affiliation not provided to SSRN and affiliation not provided to SSRN
Downloads 13 (1,579,999)

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Furin inhibitor, NMR spectroscopy, cyclic peptide, molecular modeling

2.

Structural Insights into Frog Skin-Derived Cyclic Peptides as Selective Matriptase Inhibitors

Number of pages: 35 Posted: 06 Sep 2025
Agata Gitlin-Domagalska, Malihe Hassanzadeh, Aleksandra Helbik-Maciejewska, Matthieu Lepage, Alexandre Joushomme, Antoine Désilets, Dawid Dębowski, Pierre-Luc Boudreault, Richard Leduc and Krzysztof Rolka
affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Université de Sherbrooke, University of Gdansk, Université de Sherbrooke, Université de Sherbrooke and affiliation not provided to SSRN
Downloads 24 (1,399,036)

Abstract:

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Peptide inhibitors, proteases, matriptase, cyclic peptides, non-covalent inhibition, competitive inhibition, molecular dynamics simulations