Swiss Institute of Bioinformatics, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Rutgers, The State University of New Jersey - Research Collaboratory for Structural Bioinformatics Protein Data Bank, affiliation not provided to SSRN, University of Basel - Biozentrum, Swiss Institute of Bioinformatics, affiliation not provided to SSRN, Rutgers, The State University of New Jersey - Research Collaboratory for Structural Bioinformatics Protein Data Bank, UC, San Francisco - Dept. of Biopharmaceutical Sciences and Pharmaceutical Chemistry, affiliation not provided to SSRN, Universita della Svizzera Italiana (USI Lugano) - Institute for Research in Biomedicine, École Polytechnique Fédérale de Lausanne (EPFL) - Institute of Bioengineering and University of Basel - Biozentrum