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Co-Delivery of NIR-II Semiconducting Polymer and pH-Sensitive Doxorubicin-Conjugated Prodrug for Photothermal/Chemotherapy

48 Pages Posted: 27 May 2021 Publication Status: Under Review

See all articles by Dongsheng Yu

Dongsheng Yu

Sun Yat-Sen University (SYSU) - PCFM Lab of MOE & Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable Devices

Yazhou Wang

Sun Yat-Sen University (SYSU) - PCFM Lab of MOE & Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable Devices

Jifeng Chen

Sun Yat-Sen University (SYSU) - PCFM Lab of MOE & Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable Devices

Shuang Liu

Sun Yat-Sen University (SYSU) - PCFM Lab of MOE & Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable Devices

Shaohui Deng

Sun Yat-Sen University (SYSU) - PCFM Lab of MOE & Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable Devices

Chengbo Liu

Chinese Academy of Sciences (CAS) - Research Lab for Biomedical Optics and Molecular Imaging

Iain McCulloch

University of Oxford

Wan Yue

Sun Yat-Sen University (SYSU) - PCFM Lab of MOE & Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable Devices

Du Cheng

Sun Yat-Sen University (SYSU) - PCFM Lab of MOE & Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable Devices

Abstract

Semiconducting polymer (SP) is a promising photothermal agent in antitumor application, but co-delivery of NIR-II SPs with chemotherapeutic drug remains a challenge. Here, SPs was firstly improved via backbone and alky side chain engineering, and afterward SPs and pH-sensitive prodrug copolymer PEG-PAsp(BzA- co -DIP- co -DOX) assembled into a nanoparticle PADD@SPs for photoacoustic (PA)-imaging guided combination of photothermal therapy and chemotherapy. SPs-encapsulated nanoparticles PADD@SPs exhibited a high photothermal conversion efficiency of ~48% at a relatively low power level of NIR irradiation (0.3 W/cm 2 for 5 min). DOX was rapidly released from nanoparticles in response to acidic environment within lysosome. PA and fluorescence imaging confirmed that photothermal therapy effectively drove DOX penetration inside tumor tissue, killing tumor cells survived from hyperthermia. The synergistic effect of SPs-based photothermal therapy and DOX-induced chemotherapy was verified in vivo. Overall, co-delivery of the SP and DOX using pH-sensitive nanoparticles represents a feasible strategy for photothermal therapy with potentially synergistic drug effects.

Keywords: NIR II photothermal therapy; Semiconducting polymer; co-delivery; pHsensitive drug release; Doxorubicin; Combined therapy

Suggested Citation

Yu, Dongsheng and Wang, Yazhou and Chen, Jifeng and Liu, Shuang and Deng, Shaohui and Liu, Chengbo and McCulloch, Iain and Yue, Wan and Cheng, Du, Co-Delivery of NIR-II Semiconducting Polymer and pH-Sensitive Doxorubicin-Conjugated Prodrug for Photothermal/Chemotherapy. Available at SSRN: https://ssrn.com/abstract=3854487 or http://dx.doi.org/10.2139/ssrn.3854487

Dongsheng Yu (Contact Author)

Sun Yat-Sen University (SYSU) - PCFM Lab of MOE & Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable Devices

Guangzhou, 510275
China

Yazhou Wang

Sun Yat-Sen University (SYSU) - PCFM Lab of MOE & Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable Devices

Guangzhou, 510275
China

Jifeng Chen

Sun Yat-Sen University (SYSU) - PCFM Lab of MOE & Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable Devices ( email )

Guangzhou, 510275
China

Shuang Liu

Sun Yat-Sen University (SYSU) - PCFM Lab of MOE & Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable Devices

Guangzhou, 510275
China

Shaohui Deng

Sun Yat-Sen University (SYSU) - PCFM Lab of MOE & Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable Devices ( email )

Guangzhou, 510275
China

Chengbo Liu

Chinese Academy of Sciences (CAS) - Research Lab for Biomedical Optics and Molecular Imaging

Shenzhen, 518055
China

Iain McCulloch

University of Oxford

Mansfield Road
Oxford, OX1 4AU
United Kingdom

Wan Yue

Sun Yat-Sen University (SYSU) - PCFM Lab of MOE & Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable Devices ( email )

Guangzhou, 510275
China

Du Cheng

Sun Yat-Sen University (SYSU) - PCFM Lab of MOE & Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable Devices ( email )

Guangzhou, 510275
China

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