Green Synthesis of Azo-Linked Porous Organic Polymer for Enrichment of Nitroimidazoles from Water, Shrimp and Basa Fish

Abstract

Herein, an azo-linked porous organic polymer (labeled as Res-POPs) has been fabricated using natural resveratrol as monomer via eco-friendly diazo-coupling reaction. Using Res-POPs as sorbent, a facile analytical method coupling solid-phase extraction with high performance liquid chromatography-diode array detection was developed for effective enrichment of NDZs in environmental water, shrimp and Basa fish samples. The developed method achieved satisfying analytical parameters, including good linearities (0.06 ~ 100 ng mL-1 for water, 1.8 ~ 200 ng g-1 for shrimp, and 1.5 ~ 200 ng g-1 for Basa fish) with determination coefficients above 0.995, low detection limits (0.02 ~ 0.05 ng mL-1, 0.60 ~ 1.00 ng g-1 and 0.50 ~ 0.90 ng g-1 for water, shrimp and Basa fish), high method recovery (85%~114%) and satisfactory precision with relative standard deviations below 8.2%. All the results demonstrated the promising application of the established method for the detection of NDZs in complex matrix samples.

Keywords: Porous organic polymer, Diazo-coupling, Solid-phase extraction, Nitroimidazoles, Determination