Visual Glucose Sensing Via Dispersive Liquid-Liquid Microextraction and Anion Exchange of Cspbbr3 Perovskite Nanocrystals

Abstract

A convenient, rapid, and reliable glucose sensor is especially essential in the food and beverage fields because excessive glucose intake can increase the risk of cardiovascular disease, diabetes, and hypertension. Here, a sensitive visual sensing and detection method for glucose has been successfully designed and constructed based on the dispersive liquid-phase microextraction (DLLME) technique combined with anion exchange in CsPbBr3 perovskite nanocrystals (PNCs). Benefiting not only from the enrichment effect of microextraction techniques but also from the sensitive and rapid anion-exchange capabilities of PNCs, this method displayed high sensitivity and a low detection limit of 3.25 μg/mL. To further demonstrate the feasibility, this approach was used for the determination of glucose in real samples, such as sugar-free beverages, and showed good selectivity and recoverability, ranging from 95.6% to 107.6%. Additionally, a test paper-based detection method was established, utilizing significant fluorescence color changes for sensitive, portable, and semi-quantitative detect glucose in the field.

Keywords: perovskite nanocrystals, fluorescent sensor, Glucose, visual detection