Giovanni Coppola

University of California, Los Angeles (UCLA) - Department of Neurology

1000 Veteran Avenue, Box 956939

Los Angeles, CA 90095-6939

United States

University of California, Los Angeles (UCLA) - Department of Psychiatry and Biobehavioral Sciences

760 Westwood Plaza

Los Angeles, CA 90095

United States

SCHOLARLY PAPERS

7

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331

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Scholarly Papers (7)

1.

A Nonsynonymous Mutation in PLCG2 Reduces the Risk of Alzheimer's Disease, Dementia with Lewy-Bodies and Frontotemporal Dementia, and Increases the Likelihood of Longevity

Number of pages: 37 Posted: 01 Feb 2019
Sven J. van der Lee, Olivia J. Conway, Iris Jansen, Minerva M. Carrasquillo, Luca Kleineidam, Erik van den Akker, Isabel Hernández, Kristel R. Van Eijk, Najada Stringa, Jason A. Chen, Anna Zettergren, Till F. M. Andlauer, Monica Diez-Fairen, Javier Simon-Sanchez, Alberto Lleó, Henrik Zetterberg, Marianne Nygaard, Cornelis Blauwendraat, Jeanne E. Savage, Jonas Mengel-From, Sonia Moreno-Grau, Michael Wagner, Juan Fortea, Michael J. Keogh, Kaj Blennow, Ingmar Skoog, Manuel A. Friese, Olga Pletnikova, Miren Zulaica, Carmen Lage, Itziar de Rojas, Steffi Riedel-Heller, Ignacio Illán-Gala, Wei Wei, Bernard Jeune, Adela Orellana, Florian Then Bergh, Xue Wang, Marc Hulsman, Nina Beker, Niccolo Tesí, Christopher Morris, Begoña Indakoetxea, Lyduine E. Collij, Martin Scherer, Estrella Morenas-Rodríguez, James W. Ironside, Bart. N.M. van Berckel, Daniel Alcolea, Heinz Wiendl, Samantha L. Strickland, Pau Pastor, Eloy Rodríguez Rodríguez, DESGESCO Dementia Genetics Spanish Consortium, Alzheimer Disease European DNA Biobank, IFGC International FTD-Genomics Consortium, IPDGC The International Parkinson Disease Genomics Consortium, RiMod-FTD Rsk and Modifying factors in Fronto-Temporal Dementia, Netherlands Brain Bank (NBB), Bradley F. Boeve, Ronald C. Petersen, Tanis J. Ferman, Jay A. van Gerpen, Marcel J. T. Reinders, Ryan J. Uitti, Lluis Tarraga, Wolfgang Maier, Oriol Dols-Icardo, Amit Kawalia, Maria Carolina Dalmasso, Mercè Boada, Uwe K. Zettl, Natasja M. van Schoor, Marian Beekman, Mariet Allen, Eliezer Masliah, Adolfo López de Munain, Alexander Pantelyat, Zbigniew K. Wszolek, Owen A. Ross, Dennis W. Dickson, Neill R. Graff-Radford, David Knopman, Rosa Rademakers, Afina W. Lemstra, Yolande A. L. Pijnenburg, Philip Scheltens, Thomas Gasser, Patrick F. Chinnery, Bernhard Hemmer, Martijn A. Huisman, Juan Troncoso, Fermin Moreno, Ellen A. Nohr, Thorkild I. A. Sørensen, Peter Heutink, Pascual Sánchez-Juan, Danielle Posthuma, Giovanni Coppola, Jordi Clarimón, Kaare Christensen, Nilüfer Ertekin-Taner, Sonja W. Scholz, Alfredo Ramirez, Agustin Ruiz, Eline Slagboom, Wiesje M. van der Flier and Henne Holstege
VU University Amsterdam, Mayo Clinic - Florida, VU University Amsterdam - Department of Neurology, Mayo Clinic - Florida, University of Cologne - Division of Neurogenetics and Molecular Psychiatry, Leiden University - Leiden University Medical Center (LUMC), Universitat Internacional de Catalunya, Utrecht University - Department of Neurology, VU University Amsterdam - Amsterdam Public Health Research Institute, University of California, Los Angeles (UCLA), University of Gothenburg, Max Planck Institute of Psychiatry, Hospital Universitario Mutua de Terrassa, German Center for Neurodegenerative Diseases (DZNE), Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), University of Gothenburg - Institute of Neuroscience and Physiology, University of Southern Denmark, Government of the United States of America - National Institute of Neurological Disorders and Stroke (NINDS), VU University Amsterdam, University of Southern Denmark, Universitat Internacional de Catalunya, Bonn University, Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), University of Newcastle, University of Gothenburg - Institute of Neuroscience and Physiology, University of Gothenburg, German Competence Network Multiple Sclerosis (KKNMS), Johns Hopkins University - School of Medicine, Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), affiliation not provided to SSRN, Carlos III Institute of Health, University of Leipzig - Institute for Social Medicine, Occupational Health and Public Health, Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), University of Cambridge, University of Southern Denmark, Universitat Internacional de Catalunya, German Competence Network Multiple Sclerosis (KKNMS), Mayo Clinic - Florida, VU University Amsterdam - Department of Neurology, VU University Amsterdam, VU University Amsterdam, University of Newcastle, Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), VU University Medical Center, University of Hamburg - University Medical Center Hamburg-Eppendorf, Utrecht University - University Medical Center (Utrecht), University of Edinburgh, VU University Medical Center, Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), German Competence Network Multiple Sclerosis (KKNMS), Mayo Clinic - Florida, Hospital Universitario Mutua de Terrassa, Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Independent, Independent, Independent, Independent, Independent, Independent, Mayo Clinic, Mayo Clinic, Mayo Clinic - Florida, Mayo Clinic - Florida, Delft University of Technology, Mayo Clinic - Florida, Universitat Internacional de Catalunya, University of Bonn - Department of Neurodegenerative Disease and Gerontopsychiatry, Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), University of Cologne - University Hospital of Cologne, University of Cologne - University Hospital of Cologne, Universitat Internacional de Catalunya, German Competence Network Multiple Sclerosis (KKNMS), University of Amsterdam - Amsterdam Public Health Research Institute, Leiden University - Section of Molecular Epidemiology, Mayo Clinic - Florida, Government of the United States of America - National Institutes of Health (NIH), Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Johns Hopkins University - School of Medicine, Mayo Clinic - Florida, Mayo Clinic - Florida, Mayo Clinic - Florida, Mayo Clinic - Florida, Mayo Clinic, Mayo Clinic - Florida - Department of Neuroscience, VU University Amsterdam, VU University Amsterdam, VU University Amsterdam - Department of Neurology, University of Tuebingen, University of Hamburg - University Medical Center Hamburg-Eppendorf, Technische Universität München (TUM), VU University Amsterdam - Amsterdam Public Health Research Institute, Johns Hopkins University - Department of Pathology, Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), University of Southern Denmark - Institute of Clinical Research, University of Copenhagen - Section of Metabolic Genetics, German Center for Neurodegenerative Diseases (DZNE), Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), VU University Medical Center, University of California, Los Angeles (UCLA) - Department of Neurology, Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), University of Southern Denmark, VU University Amsterdam, National Institutes of Health - Neurodegenerative Diseases Research Unit, University of Cologne - Division of Neurogenetics and Molecular Psychiatry, Universitat Internacional de Catalunya, Leiden University - Leiden University Medical Center (LUMC), University of Bonn - Institute of Innate Immunity and VU University Amsterdam - Alzheimer Center Amsterdam
Downloads 104 (496,351)
Citation 23

Abstract:

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Alzheimer's Disease, frontotemporal dementia, dementia with Lewy-bodies, progressive suprauclear palsy, Parkinson's Disease, amyotrophic lateral sclerosis, multiple sclerosis, neurodegenerative disease, longevity, PLCG2, Phospholipase C Gamma 2

2.

Disassembly of Axonal G3BP1 Aggregates by a Casein Kinase 2α mRNA Translational Switch

Number of pages: 45 Posted: 02 Dec 2019
University of South Carolina - Department of Biological Sciences, University of South Carolina - Department of Biological Sciences, Weizmann Institute of Science - Department of Biomolecular Sciences, Okinawa Institute of Science and Technology Graduate University (OIST) - Molecular Neuroscience Unit, University of South Carolina - Department of Biological Sciences, University of South Carolina - Department of Biological Sciences, University of South Carolina - Department of Biological Sciences, University of South Carolina - Department of Biological Sciences, University of South Carolina - Department of Biological Sciences, Semel Institute for Neuroscience and Human Behavior - Department of Neurology, University of California, Los Angeles (UCLA) - Department of Neurology, Weizmann Institute of Science - Department of Biomolecular Sciences and University of South Carolina - Department of Biological Sciences
Downloads 67 (645,700)

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CK2α, stress granule, axonal protein synthesis, axon growth

3.

AD-Linked TREM2 Mutation Induces Unique Microglial States Associated with Toxic Function in Tauopathy

Number of pages: 68 Posted: 16 Jul 2019
University of California, San Francisco (UCSF), Gladstone Institute of Neurological Disease, Gladstone Institute of Neurological Disease, Massachusetts Institute of Technology (MIT), Gladstone Institute of Neurological Disease, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center - Program for Computational and Systems Biology, Massachusetts Institute of Technology (MIT), Gladstone Institute of Neurological Disease, University of California, Los Angeles (UCLA) - Semel INstitute for Neuroscience and Human Behavior, Gladstone Institute of Neurological Disease, Cornell University, Cornell University, Gladstone Institute of Neurological Disease, University of California, San Francisco (UCSF) - Gladstone Institute of Neurological Disease, University College London - Department of Molecular Neuroscience, University of California, Los Angeles (UCLA) - Department of Neurology, Massachusetts Institute of Technology (MIT) and Cornell University - Weill Cornell Medicine
Downloads 54 (715,489)

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TREM2, R47H, microglia, inflammation, tauopathy, single-nuclei RNA-sequencing, Alzheimer's disease, memory impairment, synaptic function

4.

Patient-Tailored, Connectivity-Based Forecasts of Spreading Brain Atrophy

Number of pages: 43 Posted: 26 Feb 2019
University of California, San Francisco (UCSF) - Department of Neurology, University of California, San Francisco (UCSF) - Department of Neurology, University of California, San Francisco (UCSF) - Department of Epidemiology and Biostatistics, University of California, San Francisco (UCSF) - Department of Neurology, University of California, San Francisco (UCSF) - Department of Neurology, University of California, San Francisco (UCSF) - Department of Neurology, University of California, San Francisco (UCSF) - Department of Epidemiology and Biostatistics, University of California, San Francisco (UCSF) - Department of Neurology, University of California, San Francisco (UCSF) - Department of Neurology, University of California, San Francisco (UCSF) - Memory and Aging Center, University of California, San Francisco (UCSF) - Memory and Aging Center, University of California, Los Angeles (UCLA) - Department of Neurology, University of California, Los Angeles (UCLA) - Department of Neurology, University of California, San Francisco (UCSF) - Department of Neurology, University of California, San Francisco (UCSF) - Department of Neurology, University of California, San Francisco (UCSF) - Memory and Aging Center, University of California, San Francisco (UCSF) - Memory and Aging Center and University of California, San Francisco (UCSF) - Memory and Aging Center
Downloads 37 (831,372)

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Neurodegeneration; brain networks; graph theory; voxel-based morphometry; frontotemporal dementia

5.

De Novo Sequence and Copy Number Variants are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis

Number of pages: 80 Posted: 08 Jun 2018
University of California, San Francisco (UCSF) - Department of Psychiatry, University of California, San Francisco (UCSF) - Department of Psychiatry, Purdue University - Department of Biological Sciences, University of California, San Francisco (UCSF) - Department of Psychiatry, University of California, San Francisco (UCSF) - Department of Psychiatry, University of California, San Francisco (UCSF) - Department of Psychiatry, Rutgers, The State University of New Jersey - Department of Genetics, University of California, San Francisco (UCSF) - Department of Psychiatry, University of California, San Francisco (UCSF) - Department of Psychiatry, University of California, San Francisco (UCSF) - Department of Psychiatry, Purdue University - Department of Biological Sciences, Purdue University - Department of Biological Sciences, Harvard University - Center for Human Genetic Research, Yale University - Child Study Center, University of Groningen - Department of Child and Adolescent Psychiatry, Uppsala University - ​Department of Neuroscience, Uppsala University - Department of Immunology, University of California, Los Angeles (UCLA) - Department of Neurology, Harvard University - Center for Human Genetic Research, University of California, Los Angeles (UCLA) - Department of Neurology, University of Florida - Department of Psychiatry, Harvard University - Center for Human Genetic Research, Independent, Independent, Independent, Yale University - Child Study Center, Icahn School of Medicine at Mount Sinai - Department of Psychiatry, Mount Sinai Health System - Department of Psychiatry, Mount Sinai Health System - Department of Psychiatry, Rutgers, The State University of New Jersey - Department of Genetics, Rutgers, The State University of New Jersey - Department of Genetics, Rutgers, The State University of New Jersey - Department of Genetics, Purdue University - Department of Biological Sciences, University of California, San Francisco (UCSF) - Department of Psychiatry and University of California, San Francisco (UCSF) - Department of Psychiatry
Downloads 32 (872,759)

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6.

Type 2 Diabetes is a Beta Cell Protein Misfolding Disease

Number of pages: 37 Posted: 26 Jun 2020
University of California, Los Angeles (UCLA) - Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA) - Larry L. Hillblom Islet Research Center, University of California, Los Angeles (UCLA) - Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA) - Semel INstitute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA) - Larry L. Hillblom Islet Research Center, University of California, Los Angeles (UCLA) - Larry L. Hillblom Islet Research Center, University of California, Los Angeles (UCLA) - Larry L. Hillblom Islet Research Center, University of California, Davis (UCD) - Department of Neurobiology, Physiology and Behavior, University of California, Los Angeles (UCLA) - Department of Neurobiology, Physiology and Behavior, University of California, Los Angeles (UCLA) - Department of Neurology and University of California, Los Angeles (UCLA) - Larry L. Hillblom Islet Research Center
Downloads 21 (977,301)

Abstract:

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type 2 diabetes, beta cell, islet amyloid polypeptide, Alzheimer's disease, protein misfolding, cytoskeleton, Inflammation, Dedifferentiation, cell cycle, transcriptome, NF-kB, STAT3, ctnnb1, ESR1

7.

A Molecular Interactome of the Glioblastoma Perivascular Niche Reveals Integrin Binding Sialoprotein as a Key Mediator of Tumor Cell Migration

Number of pages: 60 Posted: 22 Oct 2021
University of California, Los Angeles (UCLA) - Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA) - Department of Bioengineering, University of California, Los Angeles (UCLA) - Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA) - Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA) - Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA) - Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA) - Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA) - Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA) - Department of Psychiatry and Biobehavioral Sciences, Northwestern University - Department of Cell and Developmental Biology, University of California, Los Angeles (UCLA) - Department of Pathology and Laboratory Medicine, University of California, Los Angeles (UCLA) - Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA) - Department of Neurosurgery, University of California, Los Angeles (UCLA) - Department of Psychiatry and Biobehavioral Sciences, University of Rochester Medical Center - Center for Translational Neuromedicine, University of California, Los Angeles (UCLA) - Department of Neurology, University of Tsukuba - Research and Development Center for Precision Medicine, University of California, Los Angeles (UCLA) - Department of Neurology, University of California, Los Angeles (UCLA) - Department of Bioengineering and University of California, Los Angeles (UCLA) - Department of Psychiatry and Biobehavioral Sciences
Downloads 16 (1,031,130)
Citation 1

Abstract:

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Glioblastoma, glioma, hydrogel, integrins, integrin alpha V, integrin binding sialoprotein, bone sialoprotein, blood vessel, vasculature, glioma vasculature, brain cancer, glioma stem cell, glioblastoma stem cell, A2B5, RNA sequencing, mesenchymal, proneural