Basque Research and Technology Alliance (BRTA) - Precision Medicine and Metabolism Laboratory, Basque Research and Technology Alliance (BRTA) - Precision Medicine and Metabolism Laboratory, Basque Research and Technology Alliance (BRTA) - Precision Medicine and Metabolism Laboratory, OSARTEN Kooperativa Elkarte, Basque Research and Technology Alliance (BRTA) - Precision Medicine and Metabolism Laboratory, Basque Research and Technology Alliance (BRTA) - Precision Medicine and Metabolism Laboratory, Basque Research and Technology Alliance (BRTA) - Precision Medicine and Metabolism Laboratory, Basque Research and Technology Alliance (BRTA) - Precision Medicine and Metabolism Laboratory, Medical University of Graz, Medical University of Graz, Medical University of Graz, Medical University of Graz, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of the Interior of Beira, University of the Interior of Beira, University of the Interior of Beira, Basque Research and Technology Alliance (BRTA) - CIC bioGUNE, OSI Bilbao-Basurto, OSI Bilbao-Basurto, OSI Bilbao-Basurto, University of Tübingen, University of Tübingen, University of Tübingen, University of Tübingen, Bruker Biospin GmbH, Bruker Biospin GmbH, Basque Research and Technology Alliance - NMR Platform, University of Tübingen, Basque Research and Technology Alliance (BRTA) - CIC bioGUNE, Medical University of Graz - Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, University of Milan - Department of Pathophysiology and Transplantation, University of Tübingen - University Hospitals Tübingen, Cedars Sinai Medical Center - Karsh Division of Gastroenterology and Hepatology, Basque Research and Technology Alliance (BRTA) - Precision Medicine and Metabolism Laboratory, Center for Biomedical Research in the Liver and Digestive Diseases Network (CIBERehd) - CIC bioGUNE and Basque Research and Technology Alliance (BRTA) - Precision Medicine and Metabolism Laboratory

University of Milan - Department of Pathophysiology and Transplantation, Wistar Institute, University of Milan - Department of Pathophysiology and Transplantation, University of Milan - Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Division of Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Istituto Nazionale Genetica Molecolare, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Division of Pathology, University of Milan - Department of Pathophysiology and Transplantation, University of Milan - Department of Pathophysiology and Transplantation, University of Milan - Department of Clinical Sciences and Community Health, University of Milan - Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Division of Neurosurgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Division of Neurosurgery, University of Milan - Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Division of Pathology, National Research Council (CNR) - Institute of Molecular Genetics and Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Division of Pathology

- Section of Gastroenterology and Hepatology, AstraZeneca Pharmaceuticals - Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism (CVRM), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Parma - Dipartimento di Economia, University of Gothenburg - Department of Molecular and Clinical Medicine, University of Eastern Finland - Department of Clinical Nutrition, AstraZeneca Pharmaceuticals - Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism (CVRM), AstraZeneca Pharmaceuticals - Bioscience Cardiovascular, Research and Early Development Cardiovascular, Renal and Metabolism, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Florence - Department of Experimental and Clinical Medicine, University of Eastern Finland - Department of Medicine, affiliation not provided to SSRN, AstraZeneca Pharmaceuticals - IMED Biotech Unit, - Section of Gastroenterology and Hepatology, - Biomedical Department of Internal and Specialized Medicine (DI.BI.M.I.S.), Magna Graecia University of Catanzaro - Department of Experimental and Clinical Medicine, - Section of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - General Medicine and Metabolic Diseases, University of Milan - Department of Pathophysiology and Transplantation, University of Gothenburg - Department of Molecular and Clinical Medicine and - Section of Gastroenterology and Hepatology

Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Gothenburg, University of Pennsylvania, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano - Department of Pathophysiology and Transplantation, University of Pavia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Government of the United States of America - Veterans Health Administration, VA Salt Lake City Health Care System, Government of the United States of America - Veterans Health Administration, University of Pennsylvania, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Johns Hopkins University, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Laboratory of Regenerative Medicine - Cell Factory, Independent, Government of the United States of America - VA New York Harbor Healthcare System, University of Padua, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Division of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, - Section of Gastroenterology and Hepatology, Università Cattolica di Roma - Department of Internal Medicine, Campus Bio-Medico University - Clinical Medicine and Hepatology Unit, University of Turin, University of Gothenburg - Department of Molecular and Clinical Medicine, Karolinska Institutet, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Pennsylvania, RWTH Aachen University, Karolinska Institutet and University of Milan - Department of Pathophysiology and Transplantation

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - General Medicine and Metabolic Diseases, National Research Council (CNR), University of Milan - Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan - Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Gothenburg - Department of Molecular and Clinical Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Washington - Department of Medicine, National Research Council (CNR) and University of Milan - Department of Pathophysiology and Transplantation

University of Milan - Department of Pathophysiology and Transplantation, University of Milan - Department of Pathophysiology and Transplantation, University of Gothenburg - Department of Molecular and Clinical Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Department of Transfusion Medicine and Hematology, University of Gothenburg - Department of Molecular and Clinical Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico - General Medicine and Metabolic Diseases, University of Gothenburg - Department of Molecular and Clinical Medicine, Università degli Studi di Milano - Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Scientific Direction, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Division of Gastroenterology and Hepatology, - Section of Gastroenterology and Hepatology, Università Cattolica di Roma - Department of Internal Medicine, Campus Bio-Medico University - Clinical Medicine and Hepatology Unit, University of Campania “Luigi Vanvitelli” - Division of Hepatogastroenterology, University of Eastern Finland - Institute of Public Health and Clinical Nutrition, Università di Torino - Department of Medical Sciences, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Department of Pathophysiology and Transplantation, Newcastle University - Translational and Clinical Research Institute, Università degli Studi di Udine - Clinic of Internal Medicine – Liver Unit, Università degli Studi di Milano - Department of Pathophysiology and Transplantation, Independent, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - General Medicine and Metabolic Diseases and University of Milan - Department of Pathophysiology and Transplantation

- Section of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - General Medicine and Metabolic Diseases, University of Eastern Finland - Department of Clinical Nutrition, University of Sydney - Storr Liver Centre, University of Helsinki - Department of Medicine, - Section of Gastroenterology and Hepatology, University of Milan - Department of Pathophysiology and Transplantation, - Section of Gastroenterology and Hepatology, - Section of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - General Medicine and Metabolic Diseases, - Section of Gastroenterology and Hepatology, Fondazione IRCCS Cà Granda Pad Marangoni - Translational Medicine, - Section of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Department of Pathophysiology and Transplantation, - Section of Gastroenterology and Hepatology, University of Sydney - Storr Liver Centre, University of Gothenburg - Department of Molecular and Clinical Medicine, University of Milan - Department of Pathophysiology and Transplantation and - Section of Gastroenterology and Hepatology