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Alexander P. J. Vlaar

University of Amsterdam - Department of Intensive Care

Netherlands

  • University of Amsterdam - Department of Intensive Care

SCHOLARLY PAPERS

8

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1,786

TOTAL CITATIONS

9

Scholarly Papers (8)

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1.

ICU Capacity Management During the COVID-19 Pandemic Using a Stochastic Process Simulation

INSEAD Working Paper No. 2020/20/TOM/HMI
Number of pages: 12 Posted: 07 Apr 2020 Last Revised: 18 Jul 2022
Andres Alban, Stephen E. Chick, Dave A. Dongelmans, Alexander F. van der Sluijs, W. Joost Wiersinga, Alexander P. J. Vlaar and Danielle Sent
Frankfurt School of Finance and Management, INSEAD - Technology and Operations Management, Amsterdam University Medical Centres - Department of Intensive Care Medicine, University of Amsterdam, Academic Medical Center, University of Amsterdam - Department of Intensive Care and Amsterdam UMC
Downloads 770 (80,922)
Citation 7

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2.

Anti-C5a Antibody (IFX-1) Treatment of Severe COVID-19: An Exploratory Phase 2 Randomized Controlled Trial

Number of pages: 23 Posted: 30 Jul 2020
Alexander P. J. Vlaar, Sanne de Bruin, Matthias Busch, Sjoerd Timmermans, Ingeborg E. van Zeggeren, Rutger Koning, Liora ter Horst, Esther B. Bulle, Frank E.H.P. van Baarle, Marcel C.G. van de Poll, E. Marleen Kemper, Iwan C.C. van der Horst, Marcus J. Schultz, Janneke Horn, Frederique Paulus, Lieuwe D. Bos, W. Joost Wiersinga, Martin Witzenrath, Simon Rueckinger, Korinna Pilz, Matthijs C. Brouwer, Ren-Feng Guo, Leo Heunks, Pieter van Paassen, Niels. C. Riedemann and Diederik van de Beek
University of Amsterdam - Department of Intensive Care, Department of Intensive Care, University of Amsterdam, Amsterdam UMC, Department of Immunology, Maastricht UMC+, Department of Immunology, Maastricht UMC+, Department of Neurology, University of Amsterdam, Amsterdam UMC, Amsterdam Neuroscience, University of Amsterdam - Amsterdam University Medical Centers, Department of Neurology, University of Amsterdam, Amsterdam UMC, Department of Intensive Care, University of Amsterdam, Amsterdam UMC, Department of Intensive Care, University of Amsterdam, Amsterdam UMC, Rivierenland ziekenhuis - Department of Intensive Care, Clinical Pharmacy, Amsterdam University Medical Centers, Maastricht University - Centre for Heart Failure Research, Cardiovascular Research Institute Maastricht (CARIM), Mahidol University - Mahidol-Oxford Tropical Medicine Research Unit, University of Amsterdam - Department of Intensive Care, Department of Intensive Care, University of Amsterdam, Amsterdam UMC, Department of Intensive Care, University of Amsterdam, Amsterdam UMC, Academic Medical Center, Charité - Universitätsmedizin Berlin - Department of Infectious Diseases and Respiratory Medicine, Metronomia Clinical Research GmbH, InflaRx GmbH, University of Amsterdam - Department of Neurology, nflaRx Pharmaceuticals Inc., Department of Neurology, University of Amsterdam, Amsterdam UMC, Amsterdam Neuroscience, Maastricht University - Division of Nephrology and Clinical Immunology, InflaRx GmbH and University of Amsterdam - Department of Neurology
Downloads 416 (175,046)

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COVID-19, complement cascade, randomized controlled trial

3.

Tranexamic Acid in Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis

Number of pages: 14 Posted: 28 Oct 2020
Joanna C. Dionne, Simon JW Oczkowski, Beverley J. Hunt, Massimo Antonelli, Marije Wijnberge, Jorinde Raasveld, Alexander P. J. Vlaar, ESICM Transfusion Taskforce and GUIDE Group
McMaster University - Department of Medicine, McMaster University - Department of Medicine, National Health Service (NHS), St. Thomas Hospital, Thrombosis & Haemophilia Centre, Fondazione Policlinico Universitario A. Gemelli IRCCS - Department of Anesthesia and Intensive Care Medicine, University of Amsterdam - Department of Anesthesiology, University of Amsterdam - Department of Anesthesiology, University of Amsterdam - Department of Intensive Care, Independent and Independent
Downloads 227 (336,244)

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Gastrointestinal bleeding, Tranexamic acid, Mortality, Systematic Review, Meta-analysis

4.

Time Since SARS-CoV-2 Infection and Humoral Immune Response Following BNT162b2 mRNA Vaccination

Number of pages: 14 Posted: 12 May 2021
Brent Appelman, Karlijn van der Straten, A.H. Ayesha Lavell, Michiel Schinkel, Marleen A. Slim, Meliawati Poniman, Judith A. Burger, Melissa Oomen, Khadija Tejjani, Amsterdam UMC COVID-19 S3/HCW Study Group, Alexander P. J. Vlaar, Joost Wiersinga, Yvo M. Smulders, Lonneke A. van Vught, Rogier W. Sanders, Marit J. van Gils, Marije Bomers and Jonne J. Sikkens
University of Amsterdam - Center for Experimental and Molecular Medicine, University of Amsterdam - Department of Medical Microbiology, VU University Amsterdam - Department of Internal Medicine, University of Amsterdam - Center for Experimental and Molecular Medicine, University of Amsterdam - Center for Experimental and Molecular Medicine, University of Amsterdam - Department of Medical Microbiology and Infection Prevention, University of Amsterdam - Amsterdam Institute for Infection and Immunity, University of Amsterdam - Department of Medical Microbiology, University of Amsterdam - Department of Medical Microbiology, Independent, University of Amsterdam - Department of Intensive Care, University of Amsterdam - Department of Internal Medicine, VU University Amsterdam - Department of Internal Medicine, University of Amsterdam - Center for Experimental and Molecular Medicine, University of Amsterdam - Department of Medical Microbiology, University of Amsterdam - Department of Medical Microbiology, VU University Amsterdam - Department of Internal Medicine and VU University Amsterdam - Department of Internal Medicine
Downloads 109 (645,052)
Citation 1

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5.

Cost-Effectiveness of ECPR Versus CCPR in OHCA; a Trial-Based Economic Evaluation

Number of pages: 25 Posted: 18 Jan 2024
Thijs Delnoij, Martje M. Suverein, Brigitte A.B. Essers, Renicus C. Hermanides, Luuk Otterspoor, Carlos V. Elzo Kraemer, Alexander P. J. Vlaar, Joris J. van der Heijden, Erik Scholten, Corstiaan den Uil, Sakir Akin, Jesse de Metz, Iwan C.C. van der Horst, Jos G. Maessen, Roberto Lorusso, Marcel C.G. van de Poll and INCEPTION Investigators
Maastricht University - Medical Center, Maastricht University - Medical Center, Maastricht University, Isala Hospital, Catharina Hospital, Leiden University, University of Amsterdam - Department of Intensive Care, Utrecht University - University Medical Center (Utrecht), St Antonius Hospital, Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC), HagaZiekenhuis van Den Haag, Onze Lieve Vrouwe Gasthuis (OLVG), Maastricht University - Centre for Heart Failure Research, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht University Medical Center - ECLS Centrum, Rivierenland ziekenhuis - Department of Intensive Care and Independent
Downloads 101 (684,672)

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ECMO, Resuscitation, ECPR, Cost-effectiveness

6.

The BNT162b2 mRNA SARS-CoV-2 Vaccine Induces Transient Afucosylated IgG1 in Naive But Not in Antigen-Experienced Vaccinees

Number of pages: 36 Posted: 08 Aug 2022
Julie Van Coillie, Tamas Pongracz, Johann Rahmöller, Hung-Jen Chen, Chiara E. Geyer, Lonneke A. van Vught, Jana S. Buhre, Tonći Šuštić, Thijs L. J. van Osch, Maurice Steenhuis, Willianne Hoepel, Wenjun Wang, Anne S. Lixenfeld, Jan Nouta, Sofie Keijzer, Federica Linty, Remco Visser, Mads D. Larsen, Emily L. Martin, Inga Künsting, Selina Lehrian, Vera von Kopylow, Carsten Kern, Hanna B. Lunding, Menno de Winther, Niels van Mourik, Theo Rispens, Tobias Graf, Marleen A. Slim, René P. Minnaar, Marije Bomers, Jonne J. Sikkens, Alexander P. J. Vlaar, C. Ellen van der Schoot, Jeroen den Dunnen, Manfred Wuhrer, Marc Ehlers, Gestur Vidarsson, Fatebenefratelli-Sacco Infectious Diseases Physicians Group and Amsterdam UMC COVID-19 S3/HCW Study Group
Sanquin Research - Department of Experimental Immunohematology, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Amsterdam - Center for Experimental and Molecular Medicine, University of Amsterdam - Center for Experimental and Molecular Medicine, University of Amsterdam - Center for Experimental and Molecular Medicine, affiliation not provided to SSRN, Sanquin Research, Sanquin Research, Sanquin Research - Department of Immunopathology, University of Amsterdam - Center for Experimental and Molecular Medicine, Leiden University, affiliation not provided to SSRN, affiliation not provided to SSRN, Sanquin Research - Department of Immunopathology, Sanquin Research, Sanquin Research, Sanquin Research, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Amsterdam - Amsterdam Cardiovascular Sciences, affiliation not provided to SSRN, Sanquin Research - Department of Immunopathology, affiliation not provided to SSRN, University of Amsterdam - Center for Experimental and Molecular Medicine, University of Amsterdam - University Medical Center, VU University Amsterdam - Department of Internal Medicine, VU University Amsterdam - Department of Internal Medicine, University of Amsterdam - Department of Intensive Care, Sanquin Research - Department of Experimental Immunohematology, University of Amsterdam - Center for Experimental and Molecular Medicine, Leiden University, University of Lübeck - Institute of Nutritional Medicine, Sanquin Research - Department of Immunopathology, Independent and Independent
Downloads 70 (875,328)
Citation 1

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mRNA vaccine, antibodies, glycosylation, fucosylation, COVID-19

7.

Attitudes of patients and family members towards deferred and waived consent in ECPR research, a post-hoc analysis of the INCEPTION trial

Number of pages: 36 Posted: 25 Oct 2025
Stijn EDM Eussen, Anina F. van de Koolwijk, Thijs Delnoij, Martje M. Suverein, Brigitte AB Essers, Renicus S. Hermanides, Luuk C. Otterspoor, Carlos V. Elzo Kraemer, Alexander P. J. Vlaar, Joris J. Van der Heijden, Erik Scholten, Corstiaan A. den Uil, Dinis Reis Miranda, Sakir Akin, Jesse De Metz, Iwan CC van der Horst, B Winkens, Jos G. Maessen, Roberto Lorusso and Marcel C.G. van de Poll
affiliation not provided to SSRN, affiliation not provided to SSRN, Maastricht University - Medical Center, affiliation not provided to SSRN, Maastricht University, Isala Hospital, Catharina Hospital, Leiden University - Leiden University Medical Center (LUMC), University of Amsterdam - Department of Intensive Care, affiliation not provided to SSRN, affiliation not provided to SSRN, Maasstad Hospital, Erasmus University Rotterdam (EUR) - Department of Intensive Care, Haga Hospital, affiliation not provided to SSRN, Maastricht University, Maastricht University, affiliation not provided to SSRN, Maastricht University Medical Center - ECLS Centrum and Rivierenland ziekenhuis - Department of Intensive Care
Downloads 64 (924,743)

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Out-of-hospital cardiac arrest, Extracorporeal cardiopulmonary resuscitation, informed consent, Ethics

8.

Identification of New Drugs to Counteract Anti-Spike IgG-Induced Hyperinflammation in Severe COVID-19

Number of pages: 30 Posted: 20 Jan 2023
Chiara E. Geyer, Hung-Jen Chen, Alexander P. Bye, Xue D. Manz, Denise Guerra, Tom G. Caniels, Tom PL Bijl, Guillermo R. Griffith, Willianne Hoepel, Steven W. de Taeye, Jennifer Veth, Alexander P. J. Vlaar, Amsterdam UMC COVID-19 Biobank, Gestur Vidarsson, Harm Jan Bogaard, Jurjan Aman, Jonathan M. Gibbins, Marit J. van Gils, Menno de Winther and Jeroen den Dunnen
University of Amsterdam - Center for Experimental and Molecular Medicine, University of Amsterdam - Center for Experimental and Molecular Medicine, University of Reading - School of Biological Sciences, University of Amsterdam - Department of Pulmonary Medicine, University of Amsterdam - Department of Medical Microbiology and Infection Prevention, University of Amsterdam - Department of Medical Microbiology and Infection Prevention, University of Amsterdam - Department of Medical Microbiology and Infection Prevention, University of Amsterdam - Amsterdam Cardiovascular Sciences, University of Amsterdam - Center for Experimental and Molecular Medicine, University of Amsterdam - Department of Medical Microbiology and Infection Prevention, University of Amsterdam - Center for Experimental and Molecular Medicine, University of Amsterdam - Department of Intensive Care, Independent, Sanquin Research - Department of Immunopathology, University of Amsterdam - Department of Pulmonary Medicine, University of Amsterdam - Department of Pulmonary Medicine, University of Reading - School of Biological Sciences, University of Amsterdam - Department of Medical Microbiology and Infection Prevention, University of Amsterdam - Amsterdam Cardiovascular Sciences and University of Amsterdam - Center for Experimental and Molecular Medicine
Downloads 29 (1,332,057)

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COVID-19 treatment, SYK, macrophage, FcR, entospletinib, Inflammation, IL-6, thrombosis, endothelial dysfunction, platelet