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Li Tan

Dana-Farber Cancer Institute - Department of Cancer Biology

450 Brookline Avenue

Boston, MA 02115

United States

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Scholarly Papers (1)

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Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and New Targeting Opportunities

Number of pages: 41 Posted: 23 Apr 2020
Martin Schröder, Li Tan, Jinhua Wang, Yanke Liang, Nathanael S. Gray, Stefan Knapp and Apirat Chaikuad
Goethe University Frankfurt - Institute of Pharmaceutical Chemistry, Dana-Farber Cancer Institute - Department of Cancer Biology, Dana-Farber Cancer Institute - Department of Cancer Biology, Dana-Farber Cancer Institute - Department of Cancer Biology, Harvard University - Department of Biological Chemistry and Molecular Pharmacology, Goethe University Frankfurt - Institute of Pharmaceutical Chemistry and Goethe University Frankfurt - Institute of Pharmaceutical Chemistry
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Abstract:

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mitogen-activated protein kinase kinase 7, MKK7, allosteric regulation, kinase activation, kinase inhibitor, covalent inhibitor