Polytechnic University of Marche - Department of Biomedical Sciences and Public Health, Respiratory Diseases Unit, Azienda Ospedaliero-Universitaria “Ospedali Riuniti”, Polytechnic University of Marche - Centre of Epidemiology, Biostatistics and Information Technology, 1Department of Biomedical Sciences and Public Health, Marche Polytechnic University, Respiratory Diseases Unit, “Ospedali Marche Nord”, Department of Cardio-Thoracic-Vascular Sciences and Public Health, University of Padova, Respiratory Diseases Unit, “Guido Salvini” Hospital, Air Pollution Project, Health Department “Regione Marche”, Respiratory Diseases Unit, “San Giuseppe”, Respiratory Diseases Unit, “Ospedali Marche Nord”, Polytechnic University of Marche - Department of Experimental and Clinical Medicine, Respiratory Diseases Unit, Azienda Ospedaliero-Universitaria “Ospedali Riuniti”, Emergency Unit, Azienda Ospedaliero-Universitaria “Ospedali Riuniti”, IRCCS - Ospedale San Giuseppe MultiMedica - U.O. di Pneumologia, Respiratory Diseases Unit, “Spedali Civili” Hospital, Department of Cardio-Thoracic-Vascular Sciences and Public Health, University of Padova, Emergency Unit, Azienda Ospedaliero-Universitaria “Ospedali Riuniti”, Respiratory Diseases Unit, “Spedali Civili” Hospital, GB Morgagni Hospital - Radiology Department, GB Morgagni Hospital - Pulmonary Unit, Respiratory Diseases Unit, Dept of Diseases of the Thorax, Ospedale GB Morgagni, Department of Cardio-Thoracic-Vascular Sciences and Public Health, University of Padova, Liver diseases and Transplant Unit, Azienda Ospedaliero-Universitaria “Ospedali Riuniti”, Careggi University Hospital - Department of Clinical and Experimental Medicine, Respiratory Diseases Unit “Santa Maria degli Angeli” Hospital, Pneumology Service, Azienda Sanitaria dell’Alto Adige, Respiratory Diseases Unit “Santa Maria degli Angeli” Hospital, Pulmonary Disease Unit, Department of Internal Medicine, Azienda Ospedali Riuniti, Department of Biomedical Sciences and Public Health, Università Politecnica delle Marche, Pulmonary Disease Unit, Department of Internal Medicine, Azienda Ospedali Riuniti, Department of Biomedical Sciences and Public Health, Università Politecnica delle Marche and Marche Polytechnic University - Centre of Epidemiology and Biostatistics

University of Florence - Department of Experimental and Clinical Medicine, University of Florence - Department of Experimental and Clinical Biomedical Sciences, University of Catania - Faculty of Medicine, University of Florence - Department of Experimental and Clinical Biomedical Sciences, University of Florence - Department of Statistics, Computer Science, Applications, University of Florence - Department of Experimental and Clinical Medicine, University of Florence - Department of Experimental and Clinical Medicine, University of Florence - Department of Experimental and Clinical Medicine, University of Florence - Department of Experimental and Clinical Medicine, NHS Foundation Trust, Royal Free Hospital, University of Milano-Bicocca - School of Medicine and Surgery, University Hospital of Cattinara - Department of Pulmonology, - Department of Translational Medical Sciences, - Department of Translational Medical Sciences, Università Vita-Salute San Raffaele - IRCCS San Raffaele Scientific Institute, Università Vita-Salute San Raffaele - Department of Anesthesia and Intensive Care, University of Florence - Department of Experimental and Clinical Medicine, University of Florence - Department of Experimental and Clinical Medicine, Careggi University Hospital - Department of Clinical and Experimental Medicine, Respiratory Diseases Unit, “San Giuseppe”, University of Florence - Azienda Ospedaliero Universitaria Careggi, University of Florence - Azienda Ospedaliero Universitaria Careggi, Sant’Andrea Hospital, University of Catania - Faculty of Medicine, Rugani Hospital - Radiology Unit, University of Florence - Department of Experimental and Clinical Medicine, University of Florence - Department of Experimental and Clinical Medicine, APHP Hospital Cochin, Careggi University Hospital of Florence - Infectious and Tropical Diseases Unit, University of Trieste - Cattinara Hospital, Università Vita-Salute San Raffaele - IRCCS San Raffaele Scientific Institute, Università Vita-Salute San Raffaele - IRCCS San Raffaele Scientific Institute, - Department of Translational Medical Sciences, IRCCS - Ospedale San Giuseppe MultiMedica - U.O. di Pneumologia, University of Michigan at Ann Arbor - Michigan Scleroderma Program, Nippon Medical School - Department of Allergy and Rheumatology, Università La Sapienza, University of Florence - Department of Experimental and Clinical Medicine, University of Florence - Azienda Ospedaliero Universitaria Careggi, Ca' Foncello General Hospital - Department of Radiology, University of Milano-Bicocca - S. Gerardo Hospital - Respiratory Unit, University of Catania - Faculty of Medicine, University of Florence - Department of Experimental and Clinical Biomedical Sciences and University of Florence - Department of Experimental and Clinical Medicine