Tzaneio General Hospital of Piraeus - 2 nd Department of Internal Medicine, National and Kapodistrian University of Athens Medical School - 3rd Department of Internal Medicine, - 4th Department of Internal Medicine, Thriasio General Hospital of Eleusis, Tzaneio General Hospital of Piraeus - 2 nd Department of Internal Medicine, Andreas Syggros Hospital - HIV Infection Unit, National and Kapodistrian University of Athens, University of Ioannina, National and Kapodistrian University of Athens, Hellenic Institute for the Study of Sepsis, National and Kapodistrian University of Athens Medical School - 1 st Department of Chest Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - Lazzaro Spallanzani National Institute for Infectious Diseases - INMI, Fondazione Policlinico Universitario A. Gemelli IRCCS - Section of Infectious Diseases, Hellenic Institute for the Study of Sepsis, Negrar di Valpolicella - IRCCS Sacro Cuore - Don Calabria hospital, University of Genoa - Department of Health Sciences (DISSAL), Università Vita-Salute San Raffaele - IRCCS San Raffaele Scientific Institute, University of Barcelona - Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hellenic Institute for the Study of Sepsis, G. Gennimatas General Hospital of Athens, National and Kapodistrian University of Athens, Academy of Athens - Biomedical Research Foundation, National and Kapodistrian University of Athens, Hellenic Institute for the Study of Sepsis, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens, University of Athens, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens, Academy of Athens - Biomedical Research Foundation, Democritus University of Thrace - Department of Internal Medicine, - Laiko General Hospital, Radboud University Nijmegen, Radboud University Nijmegen - Department of Internal Medicine, Radboud University Nijmegen - Department of Internal Medicine, Thriasio General Hospital of Eleusis, Hospital of Jesolo, General Hospital of Argolida, Fondazione Policlinico Universitario A. Gemelli IRCCS, Lazzaro Spallanzani National Institute for Infectious Diseases, University of Milan, National and Kapodistrian University of Athens, Thriasio General Hospital of Eleusis, University of Ioannina - 1st Department of Internal Medicine, Radboud University Nijmegen - Radboud Center for Infectious Diseases (RCI) and - 4th Department of Internal Medicine

University of Limerick, University of Groningen - University Medical Center Groningen, IRCCS Ospedale San Raffaele & Vita-Salute San Raffaele University - Unit of Immunology, Azienda Unità Sanitaria Locale (AUSL) - IRCCS di Reggio Emilia, Azienda Unità Sanitaria Locale (AUSL) - IRCCS di Reggio Emilia, Azienda Unità Sanitaria Locale (AUSL) - IRCCS di Reggio Emilia, University Hospital Marqués de Valdecilla, University of Siena, Dorset County Hospital NHS Foundation Trust, Università Vita-Salute San Raffaele - IRCCS San Raffaele Scientific Institute, University of Groningen and Anglia Ruskin University

University of Groningen - University Medical Center Groningen, University of Limerick, IRCCS Ospedale San Raffaele & Vita-Salute San Raffaele University - Unit of Immunology, University of Siena, Università Vita-Salute San Raffaele - IRCCS San Raffaele Scientific Institute, University Hospitals Dorset NHS Foundation Trust, University of Groningen - University Medical Center Groningen, Università di Modena e Reggio Emilia, Azienda Unità Sanitaria Locale (AUSL) - IRCCS di Reggio Emilia, Azienda Unità Sanitaria Locale (AUSL) - IRCCS di Reggio Emilia, University Hospital Marqués de Valdecilla and Anglia Ruskin University

University of L'Aquila, University of Siena, University of Siena, Università degli Studi di Bari “Aldo Moro” (UNIBA), UOD Reumatologia- Grande Ospedale Metropolitano, Università degli Studi di Bari “Aldo Moro” (UNIBA), University of São Paulo (USP), University of São Paulo (USP), University of São Paulo (USP), King Saud University - Department of Rheumatology, King Saud University, King Saud University, - First Department of Propaedeutic and Internal Medicine, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens, University of Campania Luigi Vanvitelli, University of Campania Luigi Vanvitelli, University of Campania Luigi Vanvitelli, Cairo University, Cairo University, University of Ferrara, University of Ferrara, Marmara University, Marmara University, Unità Operativa di Immunoreumatologia-Area Medicina Clinica Policlinico Universitario Campus Bio-Medico di Roma, Università Campus Bio-Medico di Roma, University of Perugia, University of Perugia, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - Department of Immunology and Rheumatology, University of L'Aquila - Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila - Department of Biotechnological and Applied Clinical Sciences, University of Barcelona, University of Barcelona, Università Vita-Salute San Raffaele - IRCCS San Raffaele Scientific Institute, IRCCS Ospedale San Raffaele & Vita-Salute San Raffaele University - Unit of Immunology, Medical University of Lodz - Department of Internal Medicine, Medical University of Lodz, University of Turin, University of Turin, University of Siena, University of Siena, University of Siena, University of Naples Federico II, University of Florence, University of Padua, University of Pavia, Ankara Yildirim Beyazit University - Ankara City Hospital, Sapienza University of Rome, Sapienza University of Rome, Azienda Ospedaliera Universitaria 27 (AOU), "G. Martino" Messina, University of Campania Luigi Vanvitelli, University of Catania, Mansoura University, Università degli Studi di Bari “Aldo Moro” (UNIBA), - Department PROMISE, University of Milan, Università degli Studi di Bari “Aldo Moro” (UNIBA), Università degli Studi di Bari “Aldo Moro” (UNIBA), University of Antwerp, Central Hospital of Bolzano, San Camillo Forlanini Hospital, University of Bucharest, University of Brescia, University of Verona, Fatebenefratelli Hospital, San Salvatore Hospital, National and Kapodistrian University of Athens, Gazi University, Gazi University, University of Warsaw, University of Warsaw, University of Siena, University of Siena, Fondazione Policlinico Universitario A. Gemelli IRCCS, University of Siena and Azienda Ospedaliero Universitaria di Modena - Department of Neuroscience

University of Patras - Department of Internal Medicine, - 4th Department of Internal Medicine, National and Kapodistrian University of Athens, University of Ioannina, Aristotle University of Thessaloniki, G. Gennimatas General Hospital of Athens, Elpis General Hospital - Department of Internal Medicine, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - Lazzaro Spallanzani National Institute for Infectious Diseases - INMI, Sotiria General Hospital of Chest Diseases of Athens - 2nd Department of Pulmonary Medicine, National and Kapodistrian University of Athens, General Hospital of Larissa, affiliation not provided to SSRN, Sotiria General Hospital of Chest Diseases of Athens - 10th Department of Pulmonary Medicine, Thriasio General Hospital of Eleusis - 2 nd Department of Internal Medicine, University of Brescia, Hospital of Jesolo, National and Kapodistrian University of Athens, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - Lazzaro Spallanzani National Institute for Infectious Diseases - INMI, Korgialeneion-Benakeion General Hospital, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens Medical School - Department of Therapeutics, Università Vita-Salute San Raffaele - IRCCS San Raffaele Scientific Institute, Sotiria General Hospital of Chest Diseases of Athens, Papageorgiou General Hospital of Thessaloniki - 1 st Department of Internal Medicine, affiliation not provided to SSRN, affiliation not provided to SSRN, Aristotle University of Thessaloniki, Negrar di Valpolicella - IRCCS Sacro Cuore - Don Calabria hospital, Sotiria General Hospital of Chest Diseases of Athens - 10th Department of Pulmonary Medicine, IRCCS Humanitas Research Hospital, affiliation not provided to SSRN, National and Kapodistrian University of Athens, Government of the United States of America - Veterans Affairs Medical Center (VAMC), National and Kapodistrian University of Athens, Korgialeneion-Benakeion General Hospital, General Hospital of Kerkyra - Department of Pulmonary Medicine,, Sotiria General Hospital of Chest Diseases of Athens, Fondazione Policlinico Universitario A. Gemelli IRCCS, - 4th Department of Internal Medicine, affiliation not provided to SSRN, General University Hospital of Larissa, affiliation not provided to SSRN, Radboud University Nijmegen - Radboud Center for Infectious Diseases (RCI), Democritus University of Thrace - Department of Internal Medicine, National and Kapodistrian University of Athens, University of Ioannina - 1st Department of Internal Medicine, Larissa University General Hospital - Department of Internal Medicine and - 4th Department of Internal Medicine

University of Florence - Department of Experimental and Clinical Medicine, University of Florence - Department of Experimental and Clinical Biomedical Sciences, University of Catania - Faculty of Medicine, University of Florence - Department of Experimental and Clinical Biomedical Sciences, University of Florence - Department of Statistics, Computer Science, Applications, University of Florence - Department of Experimental and Clinical Medicine, University of Florence - Department of Experimental and Clinical Medicine, University of Florence - Department of Experimental and Clinical Medicine, University of Florence - Department of Experimental and Clinical Medicine, NHS Foundation Trust, Royal Free Hospital, University of Milano-Bicocca - School of Medicine and Surgery, University Hospital of Cattinara - Department of Pulmonology, - Department of Translational Medical Sciences, - Department of Translational Medical Sciences, Università Vita-Salute San Raffaele - IRCCS San Raffaele Scientific Institute, Università Vita-Salute San Raffaele - Department of Anesthesia and Intensive Care, University of Florence - Department of Experimental and Clinical Medicine, University of Florence - Department of Experimental and Clinical Medicine, Careggi University Hospital - Department of Clinical and Experimental Medicine, Respiratory Diseases Unit, “San Giuseppe”, University of Florence - Azienda Ospedaliero Universitaria Careggi, University of Florence - Azienda Ospedaliero Universitaria Careggi, Sant’Andrea Hospital, University of Catania - Faculty of Medicine, Rugani Hospital - Radiology Unit, University of Florence - Department of Experimental and Clinical Medicine, University of Florence - Department of Experimental and Clinical Medicine, APHP Hospital Cochin, Careggi University Hospital of Florence - Infectious and Tropical Diseases Unit, University of Trieste - Cattinara Hospital, Università Vita-Salute San Raffaele - IRCCS San Raffaele Scientific Institute, Università Vita-Salute San Raffaele - IRCCS San Raffaele Scientific Institute, - Department of Translational Medical Sciences, IRCCS - Ospedale San Giuseppe MultiMedica - U.O. di Pneumologia, University of Michigan at Ann Arbor - Michigan Scleroderma Program, Nippon Medical School - Department of Allergy and Rheumatology, Università La Sapienza, University of Florence - Department of Experimental and Clinical Medicine, University of Florence - Azienda Ospedaliero Universitaria Careggi, Ca' Foncello General Hospital - Department of Radiology, University of Milano-Bicocca - S. Gerardo Hospital - Respiratory Unit, University of Catania - Faculty of Medicine, University of Florence - Department of Experimental and Clinical Biomedical Sciences and University of Florence - Department of Experimental and Clinical Medicine