Tzaneio General Hospital of Piraeus - 2 nd Department of Internal Medicine, National and Kapodistrian University of Athens Medical School - 3rd Department of Internal Medicine, - 4th Department of Internal Medicine, Thriasio General Hospital of Eleusis, Tzaneio General Hospital of Piraeus - 2 nd Department of Internal Medicine, Andreas Syggros Hospital - HIV Infection Unit, National and Kapodistrian University of Athens, University of Ioannina, National and Kapodistrian University of Athens, Hellenic Institute for the Study of Sepsis, National and Kapodistrian University of Athens Medical School - 1 st Department of Chest Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - Lazzaro Spallanzani National Institute for Infectious Diseases - INMI, Fondazione Policlinico Universitario A. Gemelli IRCCS - Section of Infectious Diseases, Hellenic Institute for the Study of Sepsis, Negrar di Valpolicella - IRCCS Sacro Cuore - Don Calabria hospital, University of Genoa - Department of Health Sciences (DISSAL), Università Vita-Salute San Raffaele - IRCCS San Raffaele Scientific Institute, University of Barcelona - Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hellenic Institute for the Study of Sepsis, G. Gennimatas General Hospital of Athens, National and Kapodistrian University of Athens, Academy of Athens - Biomedical Research Foundation, National and Kapodistrian University of Athens, Hellenic Institute for the Study of Sepsis, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens, National & Kapodistrian University of Athens, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens, Academy of Athens - Biomedical Research Foundation, Democritus University of Thrace - Department of Internal Medicine, - Laiko General Hospital, Radboud University Nijmegen, Radboud University Nijmegen - Department of Internal Medicine, Radboud University Nijmegen - Department of Internal Medicine, Thriasio General Hospital of Eleusis, Hospital of Jesolo, General Hospital of Argolida, Fondazione Policlinico Universitario A. Gemelli IRCCS, Lazzaro Spallanzani National Institute for Infectious Diseases, University of Milan, National and Kapodistrian University of Athens, Thriasio General Hospital of Eleusis, University of Ioannina - 1st Department of Internal Medicine, Radboud University Nijmegen - Radboud Center for Infectious Diseases (RCI) and - 4th Department of Internal Medicine

- 4th Department of Internal Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Jena University - Department of Anesthesiology and Intensive Care Medicine, Ludwig Maximilian University of Munich (LMU), National and Kapodistrian University of Athens, Hellenic Institute for the Study of Sepsis, Jena University - Department of Anesthesiology and Intensive Care Medicine, Catholic University of Milan, Ludwig Maximilian University of Munich (LMU) - LMU Klinikum, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens, Tzaneio General Hospital of Piraeus, General Hospital of Thessaloniki "G. Gennimatas" - Intensive Care Unit, “Aghios Dimitrios” Thessaloniki General Hospital - Intensive Care Unit, General Hospital AHEPA, Catholic University of Milan, Asklepieio General Hospital of Voula, University of Crete, Sotiria General Hospital of Chest Diseases, General Hospital AHEPA, Democritus University of Thrace, National and Kapodistrian University of Athens, Swedish Orphan Biovitrum, Catholic University of Milan, Friedrich-Schiller-Universität Jena, Aristotle University of Thessaloniki - Hippokration General Hospital and Jena University - Department of Anesthesiology and Intensive Care Medicine

University of Patras - Department of Internal Medicine, - 4th Department of Internal Medicine, National and Kapodistrian University of Athens, University of Ioannina, Aristotle University of Thessaloniki, G. Gennimatas General Hospital of Athens, Elpis General Hospital - Department of Internal Medicine, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - Lazzaro Spallanzani National Institute for Infectious Diseases - INMI, Sotiria General Hospital of Chest Diseases of Athens - 2nd Department of Pulmonary Medicine, National and Kapodistrian University of Athens, General Hospital of Larissa, affiliation not provided to SSRN, Sotiria General Hospital of Chest Diseases of Athens - 10th Department of Pulmonary Medicine, Thriasio General Hospital of Eleusis - 2 nd Department of Internal Medicine, University of Brescia, Hospital of Jesolo, National and Kapodistrian University of Athens, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - Lazzaro Spallanzani National Institute for Infectious Diseases - INMI, Korgialeneion-Benakeion General Hospital, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens Medical School - Department of Therapeutics, Università Vita-Salute San Raffaele - IRCCS San Raffaele Scientific Institute, Sotiria General Hospital of Chest Diseases of Athens, Papageorgiou General Hospital of Thessaloniki - 1 st Department of Internal Medicine, affiliation not provided to SSRN, affiliation not provided to SSRN, Aristotle University of Thessaloniki, Negrar di Valpolicella - IRCCS Sacro Cuore - Don Calabria hospital, Sotiria General Hospital of Chest Diseases of Athens - 10th Department of Pulmonary Medicine, IRCCS Humanitas Research Hospital, affiliation not provided to SSRN, National and Kapodistrian University of Athens, Government of the United States of America - Veterans Affairs Medical Center (VAMC), National and Kapodistrian University of Athens, Korgialeneion-Benakeion General Hospital, General Hospital of Kerkyra - Department of Pulmonary Medicine,, Sotiria General Hospital of Chest Diseases of Athens, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - Lazzaro Spallanzani National Institute for Infectious Diseases - INMI, - 4th Department of Internal Medicine, affiliation not provided to SSRN, General University Hospital of Larissa, affiliation not provided to SSRN, Radboud University Nijmegen - Radboud Center for Infectious Diseases (RCI), Democritus University of Thrace - Department of Internal Medicine, National and Kapodistrian University of Athens, University of Ioannina - 1st Department of Internal Medicine, Larissa University General Hospital - Department of Internal Medicine and - 4th Department of Internal Medicine

affiliation not provided to SSRN, Tzaneio General Hospital of Piraeus - 2 nd Department of Internal Medicine, - 4th Department of Internal Medicine, National and Kapodistrian University of Athens Medical School - 3rd Department of Internal Medicine, National and Kapodistrian University of Athens, Academy of Athens - Biomedical Research Foundation, Hellenic Institute for the Study of Sepsis, Sotiria General Hospital of Chest Diseases of Athens - 2nd Department of Pulmonary Medicine, Tzaneio General Hospital of Piraeus - 2 nd Department of Internal Medicine, Thriasio General Hospital of Eleusis, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens, Academy of Athens - Biomedical Research Foundation, Hellenic Institute for the Study of Sepsis, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens, Hellenic Institute for the Study of Sepsis, National and Kapodistrian University of Athens, - 4th Department of Internal Medicine, National & Kapodistrian University of Athens, Andreas Syggros Hospital - HIV Infection Unit, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens, University of Patras - Department of Internal Medicine, University of Ioannina - 1st Department of Internal Medicine, Elpis General Hospital - Department of Internal Medicine, Academy of Athens - Biomedical Research Foundation, Democritus University of Thrace - Department of Internal Medicine, Thriasio General Hospital of Eleusis - 2 nd Department of Internal Medicine, General University Hospital of Larissa - Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Center of Greece in Autoimmune Liver Diseases, European Reference Network on Hepatological Diseases, - Laiko General Hospital, Radboud University Nijmegen, Radboud University Nijmegen - Department of Internal Medicine, Radboud University Nijmegen - Department of Internal Medicine, Radboud University Nijmegen - Radboud Center for Infectious Diseases (RCI) and National and Kapodistrian University of Athens