Imperial College London - Department of Metabolism, Digestion and Reproduction, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter - IBD Pharmacogenetics Group, Imperial College Healthcare NHS Trust - Department of Medicine & Integrated Care, Imperial College London - Department of Metabolism, Digestion and Reproduction, University of Edinburgh - Centre for Inflammation Research, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Surgery and Cancer, Hull University Teaching Hospitals NHS Trust - Department of Gastroenterology, King’s College London - School of Immunology and Microbial Sciences, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, King's College Hospital - Department of Gastroenterology, University of Cambridge - NIHR BioResource, Cambridge University Hospitals NHS Trust - Department of Gastroenterology, University of Cambridge - NIHR BioResource, Barts Health NHS Trust - Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust - Department of Gastroenterology, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Immunology and Inflammation, Imperial College London, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, St Marks Hospital and Academic Institute - Department of Gastroenterology, University of Edinburgh - Centre for Inflammation Research, Royal Devon and Exeter NHS Foundation Trust - Department of Gastroenterology, Imperial College London - Department of Metabolism, Digestion and Reproduction and affiliation not provided to SSRN

University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, St Mark’s Hospital, UK IBD Registry, Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, University Hospital Southampton NHS Foundation Trust, UK IBD Registry, UK IBD Registry, University College London Hospitals NHS Foundation Trust, UK IBD Registry, Western General Hospital, NHS Lothian, King's College Hospital - Department of Gastroenterology, Hull and East Yorkshire Hospitals, Government of the United Kingdom - Leeds Teaching Hospitals, Torbay and South Devon NHS Foundation Trust, St Mark’s Hospital, Independent and UK IBD Registry

Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Infectious Disease, Imperial College London - Department of Infectious Disease, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter - IBD Pharmacogenetics Group, Imperial College Healthcare NHS Trust - Department of Medicine & Integrated Care, Imperial College London - Department of Metabolism, Digestion and Reproduction, University of Edinburgh - Centre for Inflammation Research, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Surgery and Cancer, Government of the United Kingdom - Department of Gastroenterology, Guy’s and St. Thomas NHS Foundation Trust - Department of Gastroenterology, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, King's College Hospital - Department of Gastroenterology, University of Cambridge - NIHR BioResource, University of Cambridge - NIHR BioResource, Barts Health NHS Trust - Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust - Department of Gastroenterology, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Immunology and Inflammation, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, St Marks Hospital and Academic Institute - Department of Gastroenterology, NHS Lothian - Department of Gastroenterology, Imperial College London, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Royal Devon and Exeter NHS Foundation Trust - Department of Gastroenterology, Imperial College London - Department of Metabolism, Digestion and Reproduction and Independent