Imperial College London - Department of Metabolism, Digestion and Reproduction, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter - IBD Pharmacogenetics Group, Imperial College Healthcare NHS Trust - Department of Medicine & Integrated Care, Imperial College London - Department of Metabolism, Digestion and Reproduction, University of Edinburgh - Centre for Inflammation Research, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Surgery and Cancer, Hull University Teaching Hospitals NHS Trust - Department of Gastroenterology, King’s College London - School of Immunology and Microbial Sciences, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, King's College Hospital - Department of Gastroenterology, University of Cambridge - NIHR BioResource, Cambridge University Hospitals NHS Trust - Department of Gastroenterology, University of Cambridge - NIHR BioResource, Barts Health NHS Trust - Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust - Department of Gastroenterology, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Immunology and Inflammation, Imperial College London, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, St Marks Hospital and Academic Institute - Department of Gastroenterology, University of Edinburgh - Centre for Inflammation Research, Royal Devon and Exeter NHS Foundation Trust - Department of Gastroenterology, Imperial College London - Department of Metabolism, Digestion and Reproduction and affiliation not provided to SSRN

University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Wellcome Sanger Institute, University of Exeter - Royal Devon & Exeter Hospital, NHS Foundation Trust - Cambridge University Hospitals, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter - IBD Pharmacogenetics Group, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Queen Mary University of London, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, St Marks Hospital and Academic Institute, Government of the United Kingdom - Barts Health NHS Trust, Guy’s and St Thomas’ NHS Foundation Trust, Government of the United Kingdom - Royal Wolverhampton NHS Trust, Government of the United Kingdom - Royal Wolverhampton NHS Trust, Northern Care Alliance NHS Group, St Marks Hospital and Academic Institute, Government of the United Kingdom - Hull University Teaching Hospitals NHS Trust, National Institute for Health and Care Research IBD BioResource for Translational Research, Government of the United Kingdom - Department of Gastroenterology, Government of the United Kingdom - Leeds Teaching Hospitals, Guy’s and St. Thomas NHS Foundation Trust - Department of Gastroenterology, Wellcome Sanger Institute, Torbay and South Devon NHS Foundation Trust, Bristol Genetics Laboratory, University of Exeter, University of Exeter, NHS Foundation Trust - Cambridge University Hospitals, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group and Royal Devon and Exeter NHS Foundation Trust - Department of Gastroenterology

Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter - IBD Pharmacogenetics Group, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter - Institute of Biomedical and Clinical Science, Newcastle University, Government of the United Kingdom - Department of Gastroenterology, Barts Health NHS Trust - Department of Gastroenterology, NHS Lothian - Department of Gastroenterology, Imperial College London - Department of Immunology and Inflammation, St Marks Hospital and Academic Institute - Department of Gastroenterology, Imperial College London, Imperial College London - Department of Infectious Disease, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Royal Devon and Exeter NHS Foundation Trust - Department of Gastroenterology and Imperial College London - Department of Metabolism, Digestion and Reproduction

Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Infectious Disease, Imperial College London - Department of Infectious Disease, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter - IBD Pharmacogenetics Group, Imperial College Healthcare NHS Trust - Department of Medicine & Integrated Care, Imperial College London - Department of Metabolism, Digestion and Reproduction, University of Edinburgh - Centre for Inflammation Research, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Surgery and Cancer, Government of the United Kingdom - Department of Gastroenterology, Guy’s and St. Thomas NHS Foundation Trust - Department of Gastroenterology, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Metabolism, Digestion and Reproduction, King's College Hospital - Department of Gastroenterology, University of Cambridge - NIHR BioResource, University of Cambridge - NIHR BioResource, Barts Health NHS Trust - Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust - Department of Gastroenterology, Imperial College London - Department of Metabolism, Digestion and Reproduction, Imperial College London - Department of Immunology and Inflammation, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, St Marks Hospital and Academic Institute - Department of Gastroenterology, NHS Lothian - Department of Gastroenterology, Imperial College London, University of Exeter - Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, Royal Devon and Exeter NHS Foundation Trust - Department of Gastroenterology, Imperial College London - Department of Metabolism, Digestion and Reproduction and Independent